Surface-enhanced Raman spectroscopy (SERS) studies of biomolecules

• Grant number: 17/15219-9
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: September 01, 2017
• End date: April 30, 2019
• Field of knowledge: Physical Sciences and Mathematics - Physics - Condensed Matter Physics
• Principal Investigator: Carlos José Leopoldo Constantino
• Grantee: Maria Luísa Botter de Figueiredo
• Host Institution: Faculdade de Ciências e Tecnologia (FCT). Universidade Estadual Paulista (UNESP). Campus de Presidente Prudente. Presidente Prudente , SP, Brazil
• Associated research grant: 13/14262-7 - Nanostructured films from biologically-relevant materials, AP.TEM

Abstract

Parkinson's disease and schizophrenia are related to the decrease of the concentration of the neurotransmitter dopamine in the central nervous system. In this way, our objective is to obtain SERS spectra of dopamine in the presence of ascorbic acid, uric acid, and other neurotransmitters, such as L-dopa, norepinephrine, epinephrine and serotonin, in order to evaluate the effect of this interference in the process of detection of dopamine. If there is a distinction of dopamine signals in the presence of such interferents, the SERS spectra will be used for the study of selectivity and simultaneous detection of these compounds. Gold (AuNPs) or silver (AgNPs) nanoparticles will be applied as Raman signal amplifier elements, generating the SERS signal. In this sense, seeking to optimize the signal-to-noise ratio for the SERS spectrum of dopamine, nanoparticles with different geometries will be synthesized. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

FIGUEIREDO, MARIA L. B.; MARTIN, CIBELY S.; FURINI, LEONARDO N.; RUBIRA, RAFAEL J. G.; BATAGIN-NETO, AUGUSTO; ALESSIO, PRISCILA; CONSTANTINO, CARLOS J. L.. Surface-enhanced Raman scattering for dopamine in Ag colloid: Adsorption mechanism and detection in the presence of interfering species. Applied Surface Science, v. 522, AUG 30 2020. (14/50869-6, 16/09634-0, 17/15219-9, 17/15019-0)