Evaluation of the impact of hematopoietic stem cell transplantation on the vascular aspects of systemic sclerosis

• Grant number: 17/09420-3
• Support Opportunities: Scholarships in Brazil - Master
• Start date: September 01, 2017
• End date: January 31, 2019
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Principal Investigator: Maria Carolina de Oliveira Rodrigues
• Grantee: Marianna Yumi Kawashima Vasconcelos
• Host Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil

Abstract

Systemic sclerosis (SSc) is a rheumatic disease that causes progressive fibrosis of the skin and may affect internal organs. It presents high morbidity and mortality, and in severe cases, where cutaneous involvement is diffuse or in which there is involvement of the lungs, heart or kidneys, mortality may reach 30 to 50% in five years, even under conventional immunosuppressive treatment. Autologous hematopoietic stem cell transplantation (AHSCT) has been investigated as an experimental therapeutic alternative, and has been shown effective in controlling the progression and even reversing some of the manifestations of the disease. Recently, clinical studies have demonstrated that AHSCT is superior to conventional treatments, providing longer survival, better control of disease progression and improvement of patient quality of life. However, despite the clinical benefit, there are still mechanistic questions about the therapeutic potential of AHSCT. Vasculopathy is an important component of systemic sclerosis pathogenesis, reflecting on Raynaud's phenomenon, digital ulcers, pulmonary arterial hypertension and vascular nephropathy. These manifestations correlate with the severity of the disease, poor quality of life and lower survival. Thepresent project aims, therefore, to prospectively evaluate the impact of AHSCT on the vascular aspects of the systemic sclerosis. We will prospectively evaluate levels of adhesion molecules, coagulation and platelet aggregation, systemic inflammation and oxidative stress, before and at 6 and 12 months after AHSCT. Results will be compared with those from healthy subjects. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

ZANIN-SILVA, DJULIO CESAR; SANTANA-GONCALVES, MAYNARA; KAWASHIMA-VASCONCELOS, MARIANNA YUMI; OLIVEIRA, MARIA CAROLINA. Management of Endothelial Dysfunction in Systemic Sclerosis: Current and Developing Strategies. FRONTIERS IN MEDICINE, v. 8, DEC 22 2021. (17/09420-3, 13/08135-2)

KAWASHIMA-VASCONCELOS, MARIANNA Y.; SANTANA-GONCALVES, MAYNARA; ZANIN-SILVA, DJULIO C.; MALMEGRIM, KELEN C. R.; OLIVEIRA, MARIA CAROLINA. Reconstitution of the immune system and clinical correlates after stem cell transplantation for systemic sclerosis. FRONTIERS IN IMMUNOLOGY, v. 13, p. 16-pg., 2022-08-11. (17/09420-3, 13/08135-2)