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Evaluation of the environmental risk of the interaction of microplastic, drug and antimicrobial: an ecotoxicological approach

Grant number: 17/12193-9
Support type:Scholarships in Brazil - Doctorate
Effective date (Start): September 01, 2017
Effective date (End): August 31, 2020
Field of knowledge:Physical Sciences and Mathematics - Oceanography
Principal Investigator:Camilo Dias Seabra Pereira
Grantee:Caio Rodrigues Nobre
Home Institution: Instituto de Saúde e Sociedade (ISS). Universidade Federal de São Paulo (UNIFESP). Campus Baixada Santista. Santos , SP, Brazil


Currently plastic polymers have gained worldwide attention due to the high occurrence in aquatic ecosystems, which occurs from metropolitan coastal regions to polar regions. According to the UN, in the oceans about 8 million tons of plastic are discarded per year and about 90% is composed of microplastics of industrial origin or from fragmentation of larger objects. Among the microplastic contributors to the oceans are household effluents contaminated with pharmaceuticals and personal care products (FPCP). Microplastics exhibit affinity with hydrophobic substances like synthetic hormone 17± ethinyl estradiol or bactericidal triclosan and can interact in aquatic environments acting as vectors of dispersion with potential synergistic or additive effects. In this context, the present study aims to evaluate the environmental risk of microplastics as vectors of PFPCs through an ecotoxicological approach using estuarine organisms. Biomarkers analysis at different levels of biological organization will be performed on fish tissues (Centropomus undecimalis), crab (Ucides cordatus) and oyster (Crassostrea brasiliana) exposed to virgin microplastics and marked with 17± ethinyl estradiol and triclosan. The results obtained will contribute to the understanding of the adverse effects generated by the exposure of aquatic organisms to contaminants of emerging concern, as well as their interactions in coastal ecosystems impacted by multiple sources of pollution.