Validating the Prognostic value INDEX based on two genes related to melatonin synthesis and melatonin metabolization in Colorectal and Bladder Cancer

• Grant number: 17/10291-3
• Support Opportunities: Scholarships in Brazil - Doctorate
• Start date: September 01, 2017
• End date: August 31, 2021
• Field of knowledge: Biological Sciences - Physiology
• Principal Investigator: Regina Pekelmann Markus
• Grantee: Caroline Luísa Quiles
• Host Institution: Instituto de Biociências (IB). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

Our goal is to provide proofs of concept that the production of melatonin by cancer cells of the urinary bladder and intestinal colon is a factor that reduces proliferation through the stimulation of melatonin receptors located in the tumor cell itself. The effect of each of the melatonin receptor subtypes through selective melatonin receptor agonists or mixed characteristics (agonist / antagonist) already reported in the literature will be evaluated. We emphasize that these studies can generate products to be introduced in the market, therefore these data can not be divulged. We emphasize that the procedure already provides for the publication of the data.

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

QUILES, Caroline Luísa. The Role of Endogenous and Exogenous Melatonin in Cells Derived from Urothelial Tumors. Relevance of MT1 and MT2 Receptors.. 2022. Doctoral Thesis - Universidade de São Paulo (USP). Instituto de Biociências (IBIOC/SB) São Paulo.