The possible effect of dipeptidyl peptidase-IV upon hypoglycemia prevention during exercise, in type 1 diabetic mice

• Grant number: 17/09890-0
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: September 01, 2017
• End date: February 28, 2019
• Field of knowledge: Biological Sciences - Physiology - General Physiology
• Principal Investigator: Antonio Carlos Boschiero
• Grantee: Letícia Gama e Silva Calixtro
• Host Institution: Instituto de Biologia (IB). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
• Associated research grant: 15/12611-0 - Molecular mechanisms involved in pancreatic beta cell disfunction and dead in diabetes mellitus: strategies for the inhibition of these processes and restoration of the insular mass, AP.TEM

Abstract

The physical exercise is highly recommended to type 1 diabetic (T1-D) patients, due to its benefits to this population, e.g., reduction in insulin needs, improvement of cardiorespiratory fitness, macronutrients metabolism, and skeletal-muscle function. However, the optimal exercise prescription to T1-D remains a challenge, since it is difficult to adjust the insulin dosage with the exercise. Moreover, the hypoglycemic risk is remarkable increased during and post exercise. The mainly contributors to this paradigm are: Maintenance of hyperinsulinemia, glycogen storage reduction, diminished hepatic glucose production, and glucagon secretion below the demand imposed by the hypoglycemic state. Thus, therapeutic strategies focuses on glucagon rise are promising. In this sense, dipeptidil peptidase-IV (DPP-IV) inhibition seems to be a potential candidate to prevent hypoglycemia risk in DT-1, during and post exercise, since that drug increased glucagon secretion during hyperinsulinemic-hipoglicemic clamp. Keeping it in mind, we aim to explore the effect of vildagliptina (a DPP-IV inhibitor) upon glucagon secretion and the possible efficacy of that drug in counteract the hypoglycemic events in T1-D C57BL-6 mice, during and post exercise. (AU)