Hypnotic medication dependence: a study with chronic benzodiazepine and z drug users

• Grant number: 17/11494-5
• Support Opportunities: Scholarships in Brazil - Master
• Start date: October 01, 2017
• End date: May 31, 2019
• Field of knowledge: Health Sciences - Collective Health - Public Health
• Principal Investigator: Ana Regina Noto
• Grantee: Daniela Fernández Curado
• Host Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil

Abstract

Benzodiazepines (BZD) are anxiolytic and hypnotic medication, mainly prescribed for the treatment of insomnia and anxiety. Usage of these medications should not surpass 4 weeks because of its side effects and potential to develop dependence. Even though the risks associated to consumption are well established in the litearature, there is a lack of compliance with prescription recommendations, especially regarding long-term use. Z drugs began to be marketed as safer substitutes of BZD. Since that, the number of prescriptions has grown considerably. The progression of studies with this class of medication evidences that some of the deleterious effects associated to BZD also accompany Z drugs use, including the development of dependence, but this theme is still in discussion among the scientific field and there is a lack of information on the subject for the brazilian population. This is a cross-sectional, quantitative study. The aim is to compare dependence on hypnotics among BZD and Z drugs users, via self-report instruments, in a sample broadly recruited through announcement in different medias. Participants should be 18 or older, able to read and speak portuguese and in use of hypnotic medication (BZD or Z drugs) for at least 3 months, with a frequency of use of at least once a week. The validation of the Bendep-SRQ (PV), an instrument that measures severity of hypnotic dependence, will be performed. Data analysis includes chi-square, t tests and regression models that allow the identification of differences between the groups. (AU)

Scientific publications

(4)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

DANIELA F. CURADO; VIVIAM V. DE BARROS; EMÉRITA S. OPALEYE; ANA REGINA NOTO. Psychometric properties of the Benzodiazepine Dependence Self-Report Questionnaire – Portuguese Version (BENDEP-SRQ-PV). Trends in Psychiatry and Psychotherapy, v. 42, n. 4, p. 358-367, 2020-11-25. (17/11494-5)

DANIELA F. CURADO; VIVIAM V. DE BARROS; ANA R. NOTO; EMÉRITA S. OPALEYE. Dependence on hypnotics: a comparative study between chronic users of benzodiazepines and Z-drugs. Revista Brasileira de Psiquiatria, v. 44, n. 3, p. 248-256, 2021-06-14. (17/11494-5)

CURADO, DANIELA F.; DE BARROS, VIVIAM V.; OPALEYE, EMERITA S.; NOTO, ANA REGINA. Psychometric properties of the Benzodiazepine Dependence Self-Report Questionnaire - Portuguese Version (BENDEP-SRQ-PV). Trends in Psychiatry and Psychotherapy, v. 42, n. 4, p. 10-pg., 2020-10-01. (17/11494-5)

DANIELA F. CURADO; VIVIAM V. DE BARROS; ANA R. NOTO; EMÉRITA S. OPALEYE. Dependence on hypnotics: a comparative study between chronic users of benzodiazepines and Z-drugs. Revista Brasileira de Psiquiatria, 2021-06-14. (17/11494-5)