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Developmental consequences of intrauterine exposure to cannabinoids: impact on the cardiorespiratory system and sleep-wake cycle

Grant number: 17/05318-0
Support Opportunities:Scholarships in Brazil - Doctorate
Effective date (Start): October 01, 2017
Effective date (End): December 31, 2020
Field of knowledge:Biological Sciences - Physiology - Physiology of Organs and Systems
Principal Investigator:Luciane Helena Gargaglioni Batalhão
Grantee:Luis Gustavo Alexandre Patrone
Host Institution: Faculdade de Ciências Agrárias e Veterinárias (FCAV). Universidade Estadual Paulista (UNESP). Campus de Jaboticabal. Jaboticabal , SP, Brazil

Abstract

The endocannabinoid system is already present in the CNS in the early stages of embryonic development, including in areas responsible for cardiorespiratory control. The abundance of endocannabinoids and their receptors in the CNS during development make these components important for the regulation of structural and functional maturation of the brain. The psychoactive compounds of Cannabis act directly on the endocannabinoid system, and the deleterious effects of external cannabinoids during gestation maybe related to the alterations in these pathways and physiological systems. These psychoactive components can cross the placenta and reach the developing embryo, resulting in long-lasting neurobehavioral effects to the offspring, negatively interfering with CNS formation, structuring and functioning of the cardiorespiratory system, and influencing the development and action of neurotransmitters. However, little is known about the influence of external cannabinoids on the development of the neonate. Therefore, the present study aims to evaluate the possible short, medium and long-term effects of exposure to cannabinoids during the gestational period on the cardiorespiratory control system and sleep-wake state in male and female rats. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
PATRONE, LUIS GUSTAVO A.; DUARTE, JAIME B.; BICEGO, KENIA CARDOSO; STEINER, ALEXANDRE A.; ROMANOVSKY, ANDREJ A.; GARGAGLIONI, LUCIANE H.. TRPV1 Inhibits the Ventilatory Response to Hypoxia in Adult Rats, but Not the CO2-Drive to Breathe. PHARMACEUTICALS, v. 12, n. 1, . (16/24577-3, 15/24785-2, 17/05318-0)
GARGAGLIONI, LUCIANE H.; MARQUES, DANUZIA A.; PATRONE, LUIS GUSTAVO A.. Sex differences in breathing. COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY, v. 238, . (16/04276-9, 19/09469-8, 16/24577-3, 17/05318-0)

Please report errors in scientific publications list by writing to: cdi@fapesp.br.