Knee osteoarthritis (KOA) is the most common type of chronic arthritis and its prevalence increases in parallel with population aging. This condition causes pain and inflammation of the joint capsule, muscle weakness, decreased range of motion, and physical dysfunction. As a non-pharmacological therapeutic approach, the low-level laser therapy (LLLT) is an important physical agent used in physical therapy that improves analgesia and modulates inflammatory processes. Therefore, the aim of this study is to verify if the LLLT associated with an exercise program improves additional therapeutic benefits regarding pain, physical function and quality of life in individuals with KOA. This study is a randomized double-blind placebo-controlled clinical trial. Ninety participants with symptomatic and radiographic signs of KOA studies, of both genders, aged between 40 and 75 years will be recruited for this clinical trial. They will be randomly allocated into three groups: an exercise group (EG); exercise and laser group (ELG); and exercise and sham laser group (ESG). The intervention will be performed in 12 consecutive weeks, 3 times a week. The evaluation will be performed before, at the end of the intervention and 3 months after the last session. The outcomes measures include pain intensity (visual analog scale), physical function (WOMAC and KOOS questionnaires, TUG test, stair ascend/descend test, 40 m fast-paced walk test, and 30 s chair stand test) and quality of life (SF-36 questionnaire). In order to analyze the results, a proper statistical evaluation will be performed (parametric or non-parametric tests) between the dependent variables.
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