Aplication of low-density dispersive liquid-liquid microextraction (LDS-DLLME) to identify new psychoactive substances in plasma by LC-MS/MS

• Grant number: 17/12850-0
• Support Opportunities: Scholarships in Brazil - Master
• Start date: November 01, 2017
• End date: March 31, 2019
• Field of knowledge: Biological Sciences - Pharmacology - Toxicology
• Principal Investigator: José Luiz da Costa
• Grantee: Thais Lino da Silva
• Host Institution: Faculdade de Ciências Farmacêuticas (FCF). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil

Abstract

New psychoactive substances (NPS) are synthetic drugs of abuse that provide users similar effects to those produced by "traditional" drugs, but most are not controlled by international agencies and agencies. Currently, the use of NPS has become a major public health problem worldwide, with reports of serious poisoning and deaths due to abusive use of these increasingly recurrent drugs. The objective of this project was to optimize, validate and implement a qualitative analytical methodology by HPLC-MS/MS, one of the main techniques for drug and drug analysis, which offers high sensitivity and identification capacity for toxicological analyzes. (AU)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

SILVA, Thais Lino da. Application of low-density dispersive liquid-liquid microextraction (LDS-DLLME) to identify new psychoactive substances in plasma by LC-MS/MS. 2019. Master's Dissertation - Universidade Estadual de Campinas (UNICAMP). Faculdade de Ciências Médicas Campinas, SP.