Role of kinin B1 receptor in maternal metabolism induced by physical training during the pregnancy

• Grant number: 17/21368-7
• Support Opportunities: Scholarships in Brazil - Doctorate (Direct)
• Start date: January 01, 2018
• End date: April 30, 2022
• Field of knowledge: Biological Sciences - Biochemistry - Molecular Biology
• Principal Investigator: Ronaldo de Carvalho Araújo
• Grantee: Thaís Alves da Silva
• Host Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil
• Associated research grant: 15/20082-7 - Kallikrein kinin system in physical exercise and metabolism, AP.TEM

Abstract

Kinins are involved in various aspects related to metabolism, such as glycemic, hepatic as well as in adipose tissue. Several studies have shown that the kinin B2 receptor is involved in the uptake of glucose, via GLUT4 translocation, via the insulin-independent route. This effect is probably due to an increase in intracellular calcium. On the other hand, we observed that kinin receptors play a major role in hepatic gluconeogenesis, especially in a Morbid Obesity model. In addition, B1 receptor kinins are able to modulate the leptin sensitivity in the hypothalamus of animals submitted to the high-fat diet, or in a Morbid Obesity model, the ob/ob mice. It is also known that leptin plays an important role in controlling hunger during pregnancy, as well as in the delivery of nutrients to the fetus. A resistance to maternal leptin during gestation is extremely important for the fetus to obtain the nutrients in a qualitative and quantitative way. This resistance to leptin is mainly due to inflammatory mediators, among which the B1 receptor of kinins can be highlighted. Thus, knowing that this receptor is present in the placenta and that animals deficient for the B1 receptor are more sensitive to leptin signaling, this project aims to evaluate the impact of this receptor on the pathway of hypothalamic and placental leptin. In addition, we intend to evaluate how physical exercise during pregnancy, a known factor to favor leptin signaling, will affect offspring at birth and adulthood. (AU)