Influence of vitamin D on renal development in rats

• Grant number: 17/07118-8
• Support Opportunities: Scholarships in Brazil - Doctorate
• Start date: March 01, 2018
• End date: April 30, 2021
• Field of knowledge: Biological Sciences - Physiology - Physiology of Organs and Systems
• Principal Investigator: Terezila Machado Coimbra
• Grantee: Lucas Ferreira de Almeida
• Host Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
• Associated scholarship(s): 19/02490-1 - LONG-TERM CONSEQUENCES IN ADULT LIFE OF IMPAIRED RENAL MEDULLARY MICROVASCULAR FORMATION DURING KIDNEY DEVELOPMENT, BE.EP.DR

Abstract

Rats submitted to the diet deficient in Vitamin D3 (Vit.D3) during gestation and lactation present pups with changes in renal development that persist in adult life. However, no studies have yet been performed to analyze the events related to these changes and the mechanisms involved. This study aims to analyze the influence of Vit.D3 deficiency on changes in renal development and its consequences in adult life. Evaluations of renal function and structure and blood pressure of the offspring of mothers submitted to the standard diet and of mothers who received Vit.D3-deficient diet during the gestation and lactation periods at 21, 90 and 120 days of age treated or not with calcitriol after lactation. Vit.D3 levels will be determined in serum samples collected at these times and the kidneys removed for histological studies, transmission electron microscopy, immunohistochemical, morphometric and western blot analysis. (AU)

Scientific publications

(5)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

DE ALMEIDA, LUCAS FERREIRA; COIMBRA, TEREZILA MACHADO. Neonatal hyperoxia: effects on nephrogenesis and the key role of klotho as an antioxidant factor. Journal of Maternal-Fetal & Neonatal Medicine, AUG 2020. (17/07118-8)

DE ALMEIDA, LUCAS FERREIRA; COIMBRA, TEREZILA MACHADO. When Less or More Isn't Enough: Renal Maldevelopment Arising From Disequilibrium in the Renin-Angiotensin System. FRONTIERS IN PEDIATRICS, v. 7, JUL 17 2019. (17/07118-8)

ALMEIDA, L. F.; FRANCESCATO, H. D. C.; SILVA, R. S.; SILVA, C. G. A.; ANTUNES-RODRIGUES, J.; DE PAULA, F. J. A.; COIMBRA, T. M.. Renal developmental disturbances and their long-term consequences in female pups from vitamin D-deficient mothers: involved mechanisms. JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE, v. 10, n. 4, p. 497-501, AUG 2019. (17/07118-8)

DE ALMEIDA, LUCAS FERREIRA; FRANCESCATO, HELOISA DELLA COLETTA; ANTUNES-RODRIGUES, JOSE; ALBUQUERQUE DE PAULA, FRANCISCO JOSE; ALVES DA SILVA, CLEONICE GIOVANNI; COSTA, ROBERTO SILVA; COIMBRA, TEREZILA MACHADO. Imbalance of Pro- and Anti-Angiogenic Factors Due to Maternal Vitamin D Deficiency Causes Renal Microvasculature Alterations Affecting the Adult Kidney Function. NUTRIENTS, v. 11, n. 8, AUG 2019. (17/07118-8)

DE ALMEIDA, LUCAS FERREIRA; COIMBRA, TEREZILA MACHADO. Neonatal hyperoxia: effects on nephrogenesis and the key role of klotho as an antioxidant factor. Journal of Maternal-Fetal & Neonatal Medicine, v. 35, n. 15, p. 3-pg., 2020-08-03. (17/07118-8)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

ALMEIDA, Lucas Ferreira de. Influence of vitamin D on renal development in rats. 2021. Doctoral Thesis - Universidade de São Paulo (USP). Faculdade de Medicina de Ribeirão Preto (PCARP/BC) Ribeirão Preto.