The influence of beta 2-adrenoceptor in satellite cell function

• Grant number: 17/09069-4
• Support Opportunities: Scholarships in Brazil - Doctorate
• Start date: March 01, 2018
• End date: November 30, 2021
• Field of knowledge: Biological Sciences - Morphology - Histology
• Principal Investigator: Elen Haruka Miyabara
• Grantee: Tatiana Emy Koike
• Host Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

Skeletal muscle tissue has a remarkable regenerative capacity due to the presence of muscle stem cells called satellite cells. The regeneration of injured myofibers includes the inflammatory process installation, the satellite cell activation and subsequent proliferation. Subsequently, a small population of satellite cells returns to the quiescence state and most of them differentiate to recover from previously injured muscle tissue. Although the morphological alterations that occur during muscle regeneration are well known, the molecular alterations involved in this process are not totally clarified. In this context, initial studies using treatment of synthetic beta2-adrenergic agonists in animals suggested that the beta2-adrenoceptor could be a possible regulator of the muscle regenerative process, because they demonstrated that this treatment was able to anticipate the satellite cell proliferation and enhance the structure and function of regenerating skeletal muscles. Our group also demonstrated that the beta2-adrenoceptor contributes, mainly to initial stages of muscle regeneration, being particularly involved in the regulation of macrophage recruitment to the regenerating muscle possibly through TGF-beta receptor I (Tbeta R-I) e smad2/3 activation. Furthermore, the beta2-adrenoceptor is involved in collagen remodeling during muscle regeneration, through reduction of matrix metallopeptidase 9 (MMP-9) activity. Although some works demonstrated that the beta2-adrenoceptor is important to muscle regeneration, the role of the beta2-adrenoceptor in the context of satellite cell function is not well understood. Therefore, we decided to investigate the influence of the beta2-adrenoceptor in satellite cell function. (AU)

Scientific publications

(4)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

KOIKE, TATIANA E.; DELL AQUILA, RODRIGO A.; SILVA, KELLANA S.; AOKI, MARCELO S.; MIYABARA, ELEN H.. Glutamine supplementation improves contractile function of regenerating soleus muscles from rats. JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY, v. 43, n. 2, p. 11-pg., 2022-02-24. (17/09069-4, 14/23391-8, 18/24946-4)

KOIKE, TATIANA E.; FUZIWARA, CESAR S.; BRUM, PATRICIA C.; KIMURA, EDNA T.; RANDO, THOMAS A.; MIYABARA, ELEN H.. Muscle Stem Cell Function Is Impaired in beta 2-Adrenoceptor Knockout Mice. STEM CELL REVIEWS AND REPORTS, v. N/A, p. 13-pg., 2022-03-04. (17/09069-4, 14/23391-8, 18/24946-4)

SANTOS, AUDREI R.; KOIKE, TATIANA E.; SANTANA, ALANA M.; MIRANDA, NATALYA C.; DELL AQUILA, RODRIGO A.; SILVA, THIAGO C.; AOKI, MARCELO S.; MIYABARA, ELEN H.. Glutamine supplementation accelerates functional recovery of EDL muscles after injury by modulating the expression of S100 calcium-binding proteins. Histochemistry and Cell Biology, v. 160, n. 2, p. 12-pg., 2023-05-14. (20/15351-7, 17/09069-4, 23/00289-2, 18/24946-4)

DA SILVA, MEIRICRIS TOMAZ; SANTOS, AUDREI R.; KOIKE, TATIANA E.; NASCIMENTO, TABATA L.; ROZANSKI, ANDREI; BOSNAKOVSKI, DARKO; PEREIRA, LYGIA, V; KUMAR, ASHOK; KYBA, MICHAEL; MIYABARA, ELEN H.. The fibrotic niche impairs satellite cell function and muscle regeneration in mouse models of Marfan syndrome. ACTA PHYSIOLOGICA, v. 237, n. 1, p. 19-pg., 2022-10-17. (17/14115-5, 20/15351-7, 18/24946-4, 17/09069-4, 14/23391-8, 13/04783-0, 14/13874-1)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

KOIKE, Tatiana Emy. The influence of the β2 adrenoceptor in satellite cell function.. 2021. Doctoral Thesis - Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB/SDI) São Paulo.