Advanced search
Start date

Construction and characterization of adenoviral vectors encoding the canine cDNAs for p14Arf and IFN-beta

Grant number: 17/25284-2
Support Opportunities:Scholarships in Brazil - Doctorate (Direct)
Effective date (Start): February 01, 2018
Effective date (End): March 31, 2023
Field of knowledge:Biological Sciences - Biochemistry - Molecular Biology
Principal Investigator:Bryan Eric Strauss
Grantee:Otavio Augusto Rodrigues
Host Institution: Instituto do Câncer do Estado de São Paulo Octavio Frias de Oliveira (ICESP). Coordenadoria de Serviços de Saúde (CSS). Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil
Associated research grant:15/26580-9 - Cancer gene therapy: strategic positioning for translational studies, AP.TEM


This sub-project (presented in the main proposal as project 10) describes the steps we will take to reach the proposal of a clinical gene therapy protocol for the treatment of canine Melanoma. We propose that immunotherapy with p14Arf and IFN-beta may be beneficial in the treatment of Melanoma. In preparation for pre-clinical trials of experimental gene therapy in humans, the treatment of Melanoma in dogs may reveal the proper functioning of our approach. The clinical aspects of human and canine Melanoma are similar and the treatment of dogs as demonstration of efficacy of new therapies is relevant. In the future, we hope to treat canine patients with Melanoma with our immunotherapy mediated by the adenoviral vector bearing p14Arf and IFN-beta. At the moment, we will start with the assembly and characterization of the vectors carrying the canine versions of p14Arf and IFN-beta cDNAs. (AU)

News published in Agência FAPESP Newsletter about the scholarship:
Articles published in other media outlets (0 total):
More itemsLess items

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
TESSAROLLO, NAYARA GUSMAO; DOMINGUES, ANA CAROLINA M.; ANTUNES, FERNANDA; DOS SANTOS DA LUZ, JEAN CARLOS; RODRIGUES, OTAVIO AUGUSTO; DUTRA CERQUEIRA, OTTO LUIZ; STRAUSS, BRYAN E.. Nonreplicating Adenoviral Vectors: Improving Tropism and Delivery of Cancer Gene Therapy. CANCERS, v. 13, n. 8, . (17/25290-2, 17/23068-0, 17/25284-2, 18/25555-9)

Please report errors in scientific publications list by writing to: