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Mitochondrial Ca2+ Handling in the Central Nervous System and Energy Metabolism Regulation

Grant number: 17/14713-0
Support type:Scholarships in Brazil - Doctorate
Effective date (Start): April 01, 2018
Field of knowledge:Biological Sciences - Biochemistry - Metabolism and Bioenergetics
Principal Investigator:Alicia Juliana Kowaltowski
Grantee:João Victor Cabral Costa
Home Institution: Instituto de Química (IQ). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Associated research grant:13/07937-8 - Redoxome - Redox Processes in Biomedicine, AP.CEPID
Associated scholarship(s):19/22178-2 - NCLX in astrocytic function: metabolism and neuronal homeostasis, BE.EP.DR


Ca2+ is an ion of utmost importance for the maintenance of numerous processes in the central nervous system (CNS), including neuronal development and synaptic communication and plasticity. In the mitochondrial matrix, Ca2+ induces the activity of many enzymes associated with energy metabolism, thus coupling ATP production to energetic demands under different stimuli. Hence, mitochondrial Ca2+ transport - in particular the influx through the mitochondrial calcium uniporter (MCU) and efflux through the mitochondrial Na+/Ca2+ exchanger (NCLX) - comprises a critical metabolic regulation point. Cell types across the CNS present diverse metabolic profiles, although they might be tightly coupled, as is the case of neurons and astrocytes. However, these processes are yet to be fully characterized. Therefore, this project aims to evaluate metabolic regulation exerted by the mitochondrial Ca2+ handling system, thus contributing to a better understanding of the interaction between energy metabolism and the CNS.

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
CABRAL-COSTA, J. V.; KOWALTOWSKI, A. J. Neurological disorders and mitochondria. MOLECULAR ASPECTS OF MEDICINE, v. 71, FEB 2020. Web of Science Citations: 1.
KOWALTOWSKI, ALICIA J.; MENEZES-FILHO, SERGIO L.; ASSALI, ESSAM A.; GONCALVES, ISABELA G.; CABRAL-COSTA, JOAO VICTOR; ABREU, PHABLO; MILLER, NATHANAEL; NOLASCO, PATRICIA; LAURINDO, FRANCISCO R. M.; BRUNI-CARDOSO, ALEXANDRE; SHIRIHAI, ORIAN S. Mitochondrial morphology regulates organellar Ca2+ uptake and changes cellular Ca2+ homeostasis. FASEB JOURNAL, v. 33, n. 12, p. 13176-13188, DEC 2019. Web of Science Citations: 0.

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