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Effects of hypercaloric diet associated with sedentarism in rats bone

Grant number: 17/09348-0
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): April 01, 2018
Effective date (End): May 31, 2020
Field of knowledge:Health Sciences - Medicine
Principal researcher:Antônio Carlos Shimano
Grantee:Marcio Koiti Saito
Home Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil

Abstract

Obesity is a public health problem that increases over the years due to excessive consumption of hypercaloric foods and sedentary lifestyle. There are several studies that describe hypercaloric food as a negative factor to bone quality. Therefore, the aim of this study is to evaluate the effects of a hypercaloric diet, using the cafeteria diet, associated with sedentary lifestyle in mass, strength and bone structure of rats. For this purpose, forty young male Wistar rats will be used, assigned in four groups (n = 10): animals fed a cafeteria diet (DC), animals fed a standard diet induced sedentary lifestyle (SED), animals fed a cafeteria diet induced sedentary lifestyle (DCSED) and animals fed a standard diet (CONT). After 10 experimental weeks, the blood of animals will be collected, and after two days will be submitted to euthanasia. The lefts and rights tibias and the liver of all animals will be collected for evaluation. The analyses will be performed: insulin tolerance test, analysis of liver tissue, anthropometry, macroscopic analysis of bones, bone densitometry, mechanical testing and scanning electron microscopy.