Investigation of the relationship between clinical and histopathological findings in patients with Intestinal Neuronal Dysplasia type B

• Grant number: 17/21091-5
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: March 01, 2018
• End date: February 28, 2019
• Field of knowledge: Health Sciences - Medicine - Surgery
• Principal Investigator: Pedro Luiz Toledo de Arruda Lourencao
• Grantee: Isabelle Stefan de Faria Oliveira
• Host Institution: Faculdade de Medicina (FMB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil

Abstract

Intestinal neuronal dysplasia type B (IND-B) is a pathological entity of the group of gastrointestinal neuromuscular. In most cases, this diagnosis is based on the histopathological analysis of the biopsies of rectum of patients with intestinal constipation, usually refractory to clinical treatment, demonstrating signs of submucosal nerve plexus hyperplasia. The lack of definition about the causal relationship between histological findings and clinical symptoms has been pointed out as the main point to be elucidated. Because of all of this, we decided to investigate the correlation between histopathological findings, identified in patients with IND-B, and the clinical symptoms present at the time of the diagnosis and after long-term clinical follow-up. Thus, we developed a retrospective, analytical and correlational single-centered study. It will include 29 patients, aged between 0 and 15 years, who were diagnosed with a IND-B established by histopathological analysis of biopsies of the rectum, and who had, subsequently, undergone surgical treatment by both colon and rectum extensive resections. Information from medical records will be analyzed to obtain clinical data related to the symptoms presented before treatment (minimum interval of 5 years). These information includes data related to the functional outcome of bowel habits, life quality and also the results of the application of indices to measure the results of the treatment. In addition, it will be retrieved information from the detailed histopathological analysis of the surgical parts of these same patients, including the descriptive and quantitative morphometric analysis of the submucosal nerve plexus. A correlational analysis between the main clinical variables identified and the histopathological variables analyzed in the surgical parts, will be performed. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

GONCALVES, ANDERSON CESAR; OLIVEIRA, ISABELLE STEFAN DE FARIA; HAMAMOTO FILHO, PEDRO TADAO; ORTOLAN, ERIKA VERUSKA PAIVA; TERRA, SIMONE ANTUNES; RODRIGUES, MARIA APARECIDA MARCHESAN; LOURENCAO, PEDRO LUIZ TOLEDO DE ARRUDA. Association between Clinical and Histopathological Findings in Intestinal Neuronal Dysplasia Type B: An Advance towards Its Definition as a Disease. LIFE-BASEL, v. 13, n. 5, p. 12-pg., 2023-05-12. (17/21091-5)