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IMPACT OF CORONARY ARTERY COMPLEXITY ON MORTALITY AND CARDIOVASCULAR EVENTS IN PATIENTS WITH STEMI UNDER DIFFERENT ANTIPLATELET REGIMEN

Grant number: 17/22013-8
Support Opportunities:Scholarships abroad - Research
Effective date (Start): April 01, 2018
Effective date (End): March 31, 2019
Field of knowledge:Health Sciences - Medicine - Medical Clinics
Principal Investigator:Rodrigo Gimenez Pissutti Modolo
Grantee:Rodrigo Gimenez Pissutti Modolo
Host Investigator: Patrick W. J. C. Serruys
Host Institution: Fundação de Desenvolvimento da UNICAMP (FUNCAMP). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
Research place: Erasmus University Rotterdam (EUR), Netherlands  

Abstract

The Syntax score, an index of coronary anatomic complexity and atherosclerotic burden, is already defined as a guidance for clinical decision making regarding the choice of the type of coronary revascularization. Some studies associates this marker with surrogate cardiovascular endpoints. Currently, a large clinical trial that already randomized over 16,000 patients with ST elevation myocardial infarction, is in its final follow-up phase. This GLOBAL LEADERS trial randomized STEMI patients to compare the standard dual antiplatelet therapy with ticagrelor monotherapy and only 30 days of ASA. The objective of the present study is to evaluate all 16,000 randomized patients regarding their angiographic findings of atherosclerotic burden and complexity assessed by the Syntax score, correlating it with the primary (all cause mortality) and secondary endpoints (myocardial infarction, stroke, target lesion revascularization, or definitive stent thrombosis). Also we intend to correlate these findings with the antiplatelet therapy scheme. Angiographic analysis will be performed at the Cardialysis core lab in Rotterdam - Netherlands. Our findings with this study will allow us to conclude if the assessment of the Syntax score predicts cardiovascular outcomes in a large cohort of patients, as well as better guide us on which antiplatelet therapy to prescribe in order to diminish cardiovascular morbidity and mortality.

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Scientific publications (6)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
CHICHAREON, PLY; ONUMA, YOSHINOBU; VAN KLAVEREN, DAVID; MODOLO, RODRIGO; KOGAME, NORIHIRO; TAKAHASHI, KUNIAKI; CHANG, CHUN CHIN; TOMANIAK, MARIUSZ; ASANO, TAKU; KATAGIRI, YUKI; et al. Validation of the updated logistic clinical SYNTAX score for all-cause mortality in the GLOBAL LEADERS trial. EUROINTERVENTION, v. 15, n. 6, p. E539+, . (17/22013-8)
SONCK, JEROEN; MIYAZAKI, YOSUKE; COLLET, CARLOS; ONUMA, YOSHINOBU; ASANO, TAKU; TAKAHASHI, KUNIAKI; KOGAME, NORIHIRO; KATAGIRI, YUKI; MODOLO, RODRIGO; SERRUYS, PATRICK W.; et al. Feasibility of planning coronary artery bypass grafting based only on coronary computed tomography angiography and CT-derived fractional flow reserve: a pilot survey of the surgeons involved in the randomized SYNTAX III Revolution trial. Interactive Cardiovascular and Thoracic Surgery, v. 29, n. 2, p. 209-216, . (17/22013-8)
MODOLO, RODRIGO; CHICHAREON, PLY; KOGAME, NORIHIRO; DRESSLER, OVIDIU; CROWLEY, AARON; BEN-YEHUDA, ORI; PUSKAS, JOHN; BANNING, ADRIAN; TAGGART, DAVID P.; KAPPETEIN, A. PIETER; et al. Contemporary Outcomes Following Coronary Artery Bypass Graft Surgery for Left Main Disease. Journal of the American College of Cardiology, v. 73, n. 15, p. 1877-1886, . (17/22013-8)
MODOLO, RODRIGO; CHANG, CHUN CHIN; TATEISHI, HIROKI; MIYAZAKI, YOSUKE; PIGHI, MICHELE; ABDELGHANI, MOHAMMAD; ROOS, MARTIN A.; WOLFF, QUINTEN; WYKRZYKOWSKA, JOANNA J.; DE WINTER, ROBBERT; et al. Quantitative aortography for assessing aortic regurgitation after transcatheter aortic valve implantation: results of the multicentre ASSESS-REGURGE Registry. EUROINTERVENTION, v. 15, n. 5, p. 420+, . (17/22013-8)
KOGAME, NORIHIRO; TAKAHASHI, KUNIAKI; TOMANIAK, MARIUSZ; CHICHAREON, PLY; MODOLO, RODRIGO; CHANG, CHUN CHIN; KOMIYAMA, HIDENORI; KATAGIRI, YUKI; ASANO, TAKU; STABLES, ROD; et al. Clinical Implication of Quantitative Flow Ratio After Percutaneous Coronary Intervention for 3-Vessel Disease. JACC-CARDIOVASCULAR INTERVENTIONS, v. 12, n. 20, p. 2064-2075, . (17/22013-8)
MODOLO, RODRIGO; SERRUYS, PATRICK W.; CHANG, CHUN CHIN; WOEHRLE, JOCHEN; HILDICK-SMITH, DAVID; BLEIZIFFER, SABINE; BLACKMAN, DANIEL J.; ABDEL-WAHAB, MOHAMED; ONUMA, YOSHINOBU; SOLIMAN, OSAMA; et al. Quantitative Assessment of Aortic Regurgitation After Transcatheter Aortic Valve Replacement With Videodensitometry in a Large, Real-World Study Population Subanalysis of RESPOND and Echocardiogram Association. JACC-CARDIOVASCULAR INTERVENTIONS, v. 12, n. 2, p. 216-218, . (17/22013-8)

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