| Grant number: | 17/20253-1 |
| Support Opportunities: | Scholarships in Brazil - Scientific Initiation |
| Start date: | April 01, 2018 |
| End date: | November 30, 2018 |
| Field of knowledge: | Biological Sciences - Physiology - Physiology of Organs and Systems |
| Principal Investigator: | Roberto De Pasquale |
| Grantee: | Iane Carvalho Shieh |
| Host Institution: | Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil |
Abstract Stress is related to the genesis of various neuropsychiatric diseases, such as anxiety and depression. Several changes occur in the central nervous system after exposure to stressors, such as the modulation of serotonin (5HT) release and cortisol, among other factors that compose the neural response to stress. In particular, the type 1A serotonin receptor is strongly involved in the modulation of neuronal activity in areas that participate in the stress response, like the prefrontal cortex (PFC) and the paraventricular nucleus of the hypothalamus (PVN). The aim of this project is to evaluate if there are alterations in this receptor in an animal stress model, as well as the impact of these alterations on the receptor-coupled cAMP/PKA intracellular signaling pathway. The project will also evaluate whether these effects promote behavioral changes. (AU) | |
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