Possible antidepressive effects of ketamine in lactating rats: implications on the PROLE

• Grant number: 18/05397-0
• Support Opportunities: Scholarships in Brazil - Master
• Start date: June 01, 2018
• End date: May 31, 2020
• Field of knowledge: Agronomical Sciences - Veterinary Medicine - Animal Pathology
• Agreement: Coordination of Improvement of Higher Education Personnel (CAPES)
• Principal Investigator: Helenice de Souza Spinosa
• Grantee: Gabriel Ramos de Abreu
• Host Institution: Faculdade de Medicina Veterinária e Zootecnia (FMVZ). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

Depression is one of the most common and mentally incapacitating diseases in the world. Postpartum depression is a subtype of depression that affects 1 in 7 women worldwide. It is often defined as an episode of major depressive disorder that occurs in the period after birth. The treatment for this type of depression is the combination of psychotherapies and pharmacological treatment. For pharmacological treatment, it is necessary to consider the consequences that this treatment may have on the nursing mother and the progeny, since the mother-child bond is fundamental for the general development of the progeny and, therefore, changes in the maternal behavior can generate permanent disturbances in the child. Ketamine has been widely studied for the use as an antidepressant because of its mixed mechanism of action. Taking into account that there is a trend towards increased clinical use of ketamine and that there is little information on the optimal dose and route of administration for its use as an antidepressant, as well as the safety and efficacy of a treatment during the postnatal period, further studies on the use of this drug are necessary in order to contribute to its safer clinical use. Thus, the objective of this project is to study the implications of the maternal exposure to ketamine on its progeny. For this purpose, behavioral and neurochemical studies will be performed from birth to adulthood. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

ZACCARELLI-MAGALHAES, JULIA; ABREU, GABRIEL R.; FUKUSHIMA, ANDRE R.; PANTALEON, LORENA P.; RIBEIRO, BEATRIZ B.; MUNHOZ, CAMILA; MANES, MARIANNA; DE LIMA, MAYARA A.; MIGLIOLI, JULIA; FLORIO, JORGE C.; et al. Postpartum depression in rats causes poor maternal care and neurochemical alterations on dams and long-lasting impairment in sociability on the offspring. Behavioural Brain Research, v. 436, p. 15-pg., 2023-01-05. (18/05397-0)

ZACCARELLI-MAGALHAES, JULIA; FUKUSHIMA, ANDRE RINALDI; MOREIRA, NATALIA; MANES, MARIANNA; DE ABREU, GABRIEL RAMOS; RICCI, ESTHER LOPES; WAZIRY, PAULA A. FARIA; SPINOSA, HELENICE DE SOUZA. Preclinical toxicological study of prolonged exposure to ketamine as an antidepressant. PHARMACOLOGICAL REPORTS, v. 72, n. 1, p. 24-35, FEB 2020. (18/05397-0)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

ABREU, Gabriel Ramos de. Possible antidepressant effects of ketamine in lactating rats: evaluation of implications for the offspring. 2020. Master's Dissertation - Universidade de São Paulo (USP). Faculdade de Medicina Veterinária e Zootecnia (FMVZ/SBD) São Paulo.