Role of central aldosterone in the neural control of renal function

• Grant number: 18/02194-0
• Support Opportunities: Scholarships in Brazil - Master
• Start date: June 01, 2018
• End date: September 30, 2020
• Field of knowledge: Biological Sciences - Physiology - Physiology of Organs and Systems
• Agreement: Coordination of Improvement of Higher Education Personnel (CAPES)
• Principal Investigator: Eduardo Colombari
• Grantee: Frederico Sassoli Fazan
• Host Institution: Faculdade de Odontologia (FOAr). Universidade Estadual Paulista (UNESP). Campus de Araraquara. Araraquara , SP, Brazil
• Associated research grant: 15/23467-7 - Experimental pathophysiology: role of central mechanisms of the cardiovascular and respiratory control changes induced by experimental hypertension and obesity, AP.TEM
• Associated scholarship(s): 19/09820-7 - Effects of systemic hyperkalemia: neural HSD2 activation and water balance, BE.EP.MS

Abstract

Aldosterone is a mineralocorticoid produced by the suprarenal glands with several physiological functions including the regulation of blood electrolyte content and volume. Despite of the synthesis and release of aldosterone occurring during the hypovolemic state the most intense stimulus for its release is during hyperkalemia. Aldosterone acts by binding to the intracellular mineralocorticoid receptors (MR). Since the MR has high affinity for glucocorticoids, the aldosterone sensitive cells feature a key enzyme, the 11²-Hydroxysteroid dehydrogenase type 2 (HSD2) capable of oxidizing cortisol into cortisone (an inactive form of the glucocorticoid) protecting the MR from unspecific activation. Recent studies show that the presence of HSD2 cells in the nucleus of the solitary tract (NTS) in rat and their role in the central induction of sodium appetite in the presence of aldosterone. Interestingly, some research has shown that central aldosterone has an important regulatory function controlling the sympathetic output to the heart and kidneys. Yet, the role of central aldosterone in the neural control of renal function has not been studied. The neural control of renal sodium handling has been known for decades. The renal regulation of other solutes, like potassium, is intimately associated with the sodium handling whiting the kidneys. Therefore, in the present study we will analyze the role of central aldosterone in the neural control of renal function in rats with potassium overload treatment, in the presence or not of central spironolactone (MR antagonist). (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

FAZAN, FREDERICO; COLOMBARI, DEBORA SIMOES DE ALMEIDA; MENANI, JOSE VANDERLEI; FAZAN, JR., RUBENS; COLOMBARI, EDUARDO. Electrocardiographic changes in the acute hyperkalaemia produced by intragastric KCl load in rats. Experimental Physiology, v. 106, n. 5, MAR 2021. (18/02194-0, 15/23467-7)