Pharmaceutical technology for the solubility improvement of trans-resveratrol and its application for designing of muco(bio)adhesive formulations

• Grant number: 18/10760-6
• Support Opportunities: Scholarships abroad - Research Internship - Doctorate
• Start date: June 28, 2018
• End date: September 30, 2018
• Field of knowledge: Health Sciences - Pharmacy - Pharmaceutical Technology
• Principal Investigator: Marlus Chorilli
• Grantee: Bruno da Fonseca dos Santos
• Supervisor: Eneko Larraneta
• Host Institution: Faculdade de Ciências Farmacêuticas (FCFAR). Universidade Estadual Paulista (UNESP). Campus de Araraquara. Araraquara , SP, Brazil
• Institution abroad: Queen's University Belfast, Northern Ireland
• Associated to the scholarship: 15/05394-2 - Evaluating the potential of nanostructured surfactant-based systems to intranasal administration of trans-resveratrol in the optimization of Alzheimer's disease therapy, BP.DR

Abstract

Nowadays, the pharmaceutical companies have scalable strategies for designing medicines containing poorly soluble drugs. It is estimated that approximately 60-70% of the drugs candidates have low solubility in aqueous medium and/or low permeability. So, using these strategies can to improve the absorption of drugs. Trans-resveratrol (RES) is a class II, biopharmaceutical classification system, it has low solubility in water and high permeability. Moreover, this molecule has been exhibited excellent biological properties, such as anti-inflammatory and antioxidants, which is attractive for skin and mucous membranes. The aim is to develop, characterise and evaluate the performance of nanosuspensions of RES-loaded gels and adhesives for potential application on skin and / or mucous membranes for improvement of pharmacological action.