Evaluation of bone metabolism parameters by HR-pQCT and histomorphometry in Rheumatoid Arthritis and Juvenile Idiopathic Arthritis patients: association with clinical and genetic variables

• Grant number: 18/01315-9
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• Start date: August 01, 2018
• End date: November 30, 2020
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Principal Investigator: Rosa Maria Rodrigues Pereira
• Grantee: Camille Pinto Figueiredo
• Host Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Associated research grant: 16/00006-7 - Evaluation of bone metabolism parameters by HR-pQCT and histomorphometry in rheumatoid arthritis and juvenile idiopathic arthritis patients: association with clinical and genetic variables, AP.TEM

Abstract

Rheumatoid Arthritis (RA) is a systemic disease of autoimmune nature, which leads to osteoarticular impairment. Juvenile Idiopathic Arthritis (JIA) is a group of articular disease that affects individuals under 16 years of age. The polyarticular JIA has some peculiarities of RA: symmetrical involvement of small and large joints, bone destruction and disability, if not treated properly. Individuals with RA or JIA are subject to localized bone loss (juxta-articular) and systemic bone loss. In both forms of arthritis, localized bone involvement (erosions) and generalized (Osteoporosis) lead to disability and worsening of life quality and increased morbidity and mortality. Risk factors for low bone mass in RA and JIA are multifactorial and include classical risk factors (gender, age, postmenopausal, low calcium intake and low vitamin D and smoking) as well as the intrinsic risk factors (inflammation and disease activity, immobility, and glucocorticoids use). These factors, together with a joint biomechanics changed, increase the risk of fractures. There are no studies in the literature that simultaneously evaluate the localized and generalized bone involvement in RA and JIA patients and genotype-phenotype association in relation to bone and articular involvement. The evaluation of bone involvement by more sensitive and specific cutting-edge methodologies, such as High Resolution peripheral Quantitative Computed Tomography (HR-pQCT), bone histomorphometry and Trabecular Bone Score (TBS) will bring greater prospects for understanding the mechanisms associated with bone involvement in these diseases and help to treat these complications. (AU)

Scientific publications

(7)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

FIGUEIREDO, CAMILLE P.; PEREZ, MARIANA O.; SALES, LUCAS PEIXOTO; SCHETT, GEORG; PEREIRA, ROSA M. R.. HR-pQCTin vivoimaging of periarticular bone changes in chronic inflammatory diseases: Data from acquisition to impact on treatment indications. MODERN RHEUMATOLOGY, AUG 2020. (16/00006-7, 18/01315-9)

FIGUEIREDO, CAMILLE PINTO; PEREZ, MARIANA ORTEGA; SALES, LUCAS PEIXOTO; DOMICIANO, DIOGO SOUZA; SAMPAIO-BARROS, MARILIA M.; CAPARBO, VALERIA DE FALCO; RODRIGUES PEREIRA, ROSA MARIA. Lower hand grip in rheumatoid arthritis patients is associated with low finite element analysis using high resolution peripheral quantitative computed tomography scan of the 2nd metacarpophalangeal joint. INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES, v. N/A, p. 8-pg., 2022-06-29. (16/00006-7, 18/01315-9)

PEREZ, MARIANA O.; FIGUEIREDO, CAMILLE P.; SALES, LUCAS P.; MEDEIROS-RIBEIRO, ANA CRISTINA; TAKAYAMA, LILIAM; DOMICIANO, DIOGO S.; BONFIGLIOLI, KARINA; CAPARBO, VALERIA F.; PEREIRA, ROSA M. R.. ssociation of Bone Erosions and Osteophytes With Systemic Bone Involvement on High-Resolution Peripheral Quantitative Computed Tomography in Premenopausal Women With Longstanding Rheumatoid Arthriti. ARTHRITIS & RHEUMATOLOGY, v. 74, n. 3, p. 407-417, MAR 2022. (16/00006-7, 18/01315-9, 18/05596-2)

FIGUEIREDO, CAMILLE P.; PEREZ, MARIANA O.; SALES, LUCAS PEIXOTO; SCHETT, GEORG; PEREIRA, ROSA M. R.. HR-pQCTin vivoimaging of periarticular bone changes in chronic inflammatory diseases: Data from acquisition to impact on treatment indications. MODERN RHEUMATOLOGY, v. 31, n. 2, p. 9-pg., 2020-08-28. (16/00006-7, 18/01315-9)

FIGUEIREDO, CAMILLE; PEREZ, MARIANA; DE MEDEIROS RIBEIRO, ANA CRISTINA; CAPARBO, VALERIA; PEREIRA, ROSA. Cortical Bone Erosion in the 2nd Metacarpal Bone Head: Association with Its Bone Mineral Density by HR-pQCT in Rheumatoid Arthritis Patients. ARTHRITIS & RHEUMATOLOGY, v. 71, p. 2-pg., 2019-10-01. (18/01315-9, 16/00006-7)

FIGUEIREDO, CAMILLE P.; PEREZ, MARIANA O.; SALES, LUCAS PEIXOTO; MEDEIROS, ANA CRISTINA; CAPARBO, VALERIA F.; PEREIRA, ROSA M. R.. Bone erosion in the 2nd metacarpophalangeal head: association with its bone mineral density by HR-pQCT in rheumatoid arthritis patients. BMC MUSCULOSKELETAL DISORDERS, v. 22, n. 1, JAN 25 2021. (18/01315-9, 16/00006-7)

FIGUEIREDO, CAMILLE PINTO; PEREZ, MARIANA ORTEGA; SALES, LUCAS PEIXOTO; CAPARBO, VALERIA DE FALCO; RODRIGUES PEREIRA, ROSA MARIA. Evaluation of bone erosion in rheumatoid arthritis patients by high-resolution peripheral quantitative computed tomography scans: Comparison between two semi-automated programs in a three-dimensional setting. INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES, v. 24, n. 7, JUN 2021. (16/00006-7, 18/01315-9)