Evaluation of bone metabolism parameters by HR-pQCT and histomorphometry in rheumatoid arthritis and juvenile idiopathic arthritis patients: association with clinical and genetic variables

• Grant number: 16/00006-7
• Support Opportunities: Research Projects - Thematic Grants
• Duration: August 01, 2017 - July 31, 2024
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Principal Investigator: Eduardo Ferreira Borba Neto
• Grantee: Eduardo Ferreira Borba Neto
• Host Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Pesquisadores principais: Vanda Jorgetti
• Associated researchers: Alexandre da Costa Pereira ; Diogo Souza Domiciano ; Luciene Machado dos Reis ; Nádia Emi Aikawa ; Vanda Jorgetti
• Associated grant(s): 23/01320-0 - Impact of visceral adipose tissue and whole-body adipose tissue on lean mass, muscle strength, inflammatory cytokines and bone microarchitecture in women with Rheumatoid Arthritis, AP.R; 20/05752-4 - Vitamin D supplementation in patients with COVID-19: randomized, double-blind and placebo controlled clinical trial, AP.R; 17/17383-0 - Multi-user equipment approved in grant 16/00006-7: OsteoMeasure - high resolution digital video system, AP.EMU
• Associated scholarship(s): 22/02638-1 - Evaluation of Bone Metabolism Parameters by HR-pQCT and Histomorphometry in Rheumatoid Arthritis and Juvenile Idiopathic Arthritis Patients: Association with Clinical and Genetic Variables, BP.TT; 20/14223-5 - Evaluation of Bone Metabolism Parameters by HR-pQCT and Histomorphometry in Rheumatoid Arthritis and Juvenile Idiopathic Arthritis Patients: Association with Clinical and Genetic Variables, BP.PD; 20/14599-5 - Evaluation of bone metabolism parameters by HR-pQCT and histomorphometry in Rheumatoid Arthritis and Juvenile Idiopathic Arthritis Patients: association with clinical and genetic variables, BP.IC; + associated scholarships 19/24782-4 - Comparison of mechanisms of bone loss in patients undergoing Roux-en-Y gastric bypass or sleeve gastrectomy, BP.PD; 18/01315-9 - Evaluation of bone metabolism parameters by HR-pQCT and histomorphometry in Rheumatoid Arthritis and Juvenile Idiopathic Arthritis patients: association with clinical and genetic variables, BP.PD; 18/07135-2 - Evaluation of Bone Metabolism Parameters by HR-pQCT and Histomorphometry in Rheumatoid Arthritis and Juvenile Idiopathic Arthritis Patients: Association with Clinical and Genetic Variables, BP.PD; 18/05596-2 - Evaluation of bone parameters obtained by histomorphometry, HR-pQCT and trabecular bone score in patients with Rheumatoid Arthritis, BP.DD; 18/03763-9 - Evaluation of bone metabolism parameters by HR-pQCT and histomorphometry in rheumatoid arthritis and juvenile idiopathic arthritis patients: association with clinical and genetic variables, BP.TT - associated scholarships

Abstract

Rheumatoid Arthritis (RA) is a systemic disease of autoimmune nature, which leads to osteoarticular impairment. Juvenile Idiopathic Arthritis (JIA) is a group of articular disease that affects individuals under 16 years of age. The polyarticular JIA has some peculiarities of RA: symmetrical involvement of small and large joints, bone destruction and disability, if not treated properly. Individuals with RA or JIA are subject to localized bone loss (juxta-articular) and systemic bone loss. In both forms of arthritis, localized bone involvement (erosions) and generalized (osteoporosis) lead to disability and worsening of life quality and increased morbidity and mortality. Risk factors for low bone mass in RA and JIA are multifactorial and include classical risk factors (gender, age, postmenopausal, low calcium intake and low vitamin D and smoking) as well as the intrinsic risk factors (inflammation and disease activity, immobility, and glucocorticoids use). These factors, together with a joint biomechanics changed, increase the risk of fractures. There are no studies in the literature that simultaneously evaluate the localized and generalized bone involvement in RA and JIA patients and genotype-phenotype association in relation to bone and articular involvement. The evaluation of bone involvement by more sensitive and specific cutting-edge methodologies, such as High Resolution peripheral Quantitative Computed Tomography (HR-pQCT), bone histomorphometry and Trabecular Bone Score (TBS) will bring greater prospects for understanding the mechanisms associated with bone involvement in these diseases and help to treat these complications. (AU)

Scientific publications

(18)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

REIS, BRUNA Z.; FERNANDES, ALAN L.; SALES, LUCAS P.; SANTOS, MAYARA D.; DOS SANTOS, CAROLINE C.; PINTO, ANA J.; GOESSLER, KARLA F.; FRANCO, ANDRE S.; DURAN, CAMILA S. C.; SILVA, CARLA B. R.; et al. Influence of vitamin D status on hospital length of stay and prognosis in hospitalized patients with moderate to severe COVID-19: a multicenter prospective cohort study. AMERICAN JOURNAL OF CLINICAL NUTRITION, v. 114, n. 2, p. 598-604, AUG 2021. (17/13552-2, 15/26937-4, 19/18039-7, 16/00006-7, 20/05752-4, 19/24782-4, 20/11102-2)

FIGUEIREDO, CAMILLE PINTO; PEREZ, MARIANA ORTEGA; SALES, LUCAS PEIXOTO; CAPARBO, VALERIA DE FALCO; RODRIGUES PEREIRA, ROSA MARIA. Evaluation of bone erosion in rheumatoid arthritis patients by high-resolution peripheral quantitative computed tomography scans: Comparison between two semi-automated programs in a three-dimensional setting. INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES, v. 24, n. 7, JUN 2021. (16/00006-7, 18/01315-9)

PINTO, ANA J.; GOESSLER, KARLA F.; FERNANDES, ALAN L.; MURAI, IGOR H.; SALES, LUCAS P.; REIS, BRUNA Z.; SANTOS, MAYARA DINIZ; ROSCHEL, HAMILTON; PEREIRA, ROSA M. R.; GUALANO, BRUNO. No independent associations between physical activity and clinical outcomes among hospitalized patients with moderate to severe COVID-19. JOURNAL OF SPORT AND HEALTH SCIENCE, v. 10, n. 6, p. 690-696, DEC 2021. (16/00006-7, 20/05752-4, 15/26937-4, 19/18039-7, 19/24782-4, 17/13552-2, 20/11102-2)

MAZZOLANI, BRUNA CARUSO; SMAIRA, FABIANA INFANTE; ASTLEY, CAMILLA; IRAHA, AMANDA YURI; PINTO, ANA JESSICA; MARQUES, ISABELA GOUVEIA; CORDEIRO AMARANTE, MILLA; REZENDE, NATHALIA SAFFIOTI; SIECZKOWSKA, SOFIA MENDES; FRANCO, TATHIANE CHRISTINE; et al. Changes in Eating Habits and Sedentary Behavior During the COVID-19 Pandemic in Adolescents With Chronic Conditions. FRONTIERS IN PEDIATRICS, v. 9, DEC 13 2021. (19/20814-9, 19/14819-8, 19/14820-6, 16/00006-7, 17/13552-2, 19/15231-4, 15/03756-4, 15/26937-4)

MURAI, IGOR H.; FERNANDES, ALAN L.; SALES, LUCAS P.; PINTO, ANA J.; GOESSLER, KARLA F.; DURAN, CAMILA S. C.; SILVA, CARLA B. R.; FRANCO, ANDRE S.; MACEDO, MARINA B.; DALMOLIN, HENRIQUE H. H.; et al. Effect of a Single High Dose of Vitamin D-3 on Hospital Length of Stay in Patients With Moderate to Severe COVID-19 A Randomized Clinical Trial. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, v. 325, n. 11, p. 8-pg., 2021-02-17. (20/11102-2, 16/00006-7, 19/24782-4, 15/26937-4, 19/18039-7, 20/05752-4, 17/13552-2)

ISABELA GOUVEIA MARQUES; CAMILLA ASTLEY; SOFIA MENDES SIECZKOWSKA; AMANDA YURI IRAHA; TATHIANE CHRISTINE FRANCO; FABIANA INFANTE SMAIRA; BRUNA CARUSO MAZZOLANI; LUANA CRISTINA DO AMARAL MIRANDA; BIANCA PIRES IHARA; ROSA MARIA R. PEREIRA; et al. Lessons learned from a home-based exercise program for adolescents with pre-existing chronic diseases during the COVID-19 quarantine in Brazil. Clinics, v. 76, 2021-06-28. (16/00006-7, 19/20814-9, 19/14819-8, 19/15231-4, 17/13552-2, 15/03756-4, 19/14820-6)

NETO, LEVI H. JALES; HOUNKPE, BIDOSSESSI W.; FERNANDES, GEORGEA H.; TAKAYAMA, LILIAM; LOPES, NEUZA H. M.; PEREIRA, ALEXANDRE C.; PEREIRA, ROSA M. R.. Transcriptomic analysis of elderly women with low muscle mass: association with immune system pathway. AGING-US, v. 13, n. 17, p. 20992-21008, SEP 15 2021. (16/00006-7, 20/14223-5)

FIGUEIREDO, CAMILLE P.; PEREZ, MARIANA O.; SALES, LUCAS PEIXOTO; MEDEIROS, ANA CRISTINA; CAPARBO, VALERIA F.; PEREIRA, ROSA M. R.. Bone erosion in the 2nd metacarpophalangeal head: association with its bone mineral density by HR-pQCT in rheumatoid arthritis patients. BMC MUSCULOSKELETAL DISORDERS, v. 22, n. 1, JAN 25 2021. (18/01315-9, 16/00006-7)

MURAI, IGOR H.; FERNANDES, ALAN L.; SALES, LUCAS P.; PINTO, ANA J.; GOESSLER, KARLA F.; DURAN, CAMILA S. C.; SILVA, CARLA B. R.; FRANCO, ANDRE S.; MACEDO, MARINA B.; DALMOLIN, HENRIQUE H. H.; et al. Effect of a Single High Dose of Vitamin D-3 on Hospital Length of Stay in Patients With Moderate to Severe COVID-19 A Randomized Clinical Trial. JAMA, v. 325, n. 11, FEB 2021. (20/11102-2, 15/26937-4, 17/13552-2, 19/24782-4, 19/18039-7, 20/05752-4, 16/00006-7)

JALES NETO, LEVI H.; WICIK, ZOFIA; TORRES, GEORGEA H. F.; TAKAYAMA, LILIAM; CAPARBO, VALERIA F.; LOPES, NEUZA H. M.; PEREIRA, ALEXANDRE C.; PEREIRA, ROSA M. R.. Overexpression of SNTG2, TRAF3IP2, and ITGA6 transcripts is associated with osteoporotic vertebral fracture in elderly women from community. MOLECULAR GENETICS & GENOMIC MEDICINE, JUN 2020. (16/00006-7)

FIGUEIREDO, CAMILLE P.; PEREZ, MARIANA O.; SALES, LUCAS PEIXOTO; SCHETT, GEORG; PEREIRA, ROSA M. R.. HR-pQCTin vivoimaging of periarticular bone changes in chronic inflammatory diseases: Data from acquisition to impact on treatment indications. MODERN RHEUMATOLOGY, AUG 2020. (16/00006-7, 18/01315-9)

PEREZ, MARIANA O.; FIGUEIREDO, CAMILLE P.; SALES, LUCAS P.; MEDEIROS-RIBEIRO, ANA CRISTINA; TAKAYAMA, LILIAM; DOMICIANO, DIOGO S.; BONFIGLIOLI, KARINA; CAPARBO, VALERIA F.; PEREIRA, ROSA M. R.. ssociation of Bone Erosions and Osteophytes With Systemic Bone Involvement on High-Resolution Peripheral Quantitative Computed Tomography in Premenopausal Women With Longstanding Rheumatoid Arthriti. ARTHRITIS & RHEUMATOLOGY, v. 74, n. 3, p. 407-417, MAR 2022. (16/00006-7, 18/01315-9, 18/05596-2)

ESTEVES, GABRIEL P.; MAZZOLANI, BRUNA CARUSO; SMAIRA, FABIANA INFANTE; MENDES, ELIZABETH SILVA; DE OLIVEIRA, GABRIELA GUIMARAES; ROSCHEL, HAMILTON; GUALANO, BRUNO; PEREIRA, ROSA MARIA R.; DOLAN, EIMEAR. Nutritional recommendations for patients undergoing prolonged glucocorticoid therapy. RHEUMATOLOGY ADVANCES IN PRACTICE, v. 6, n. 2, p. 13-pg., 2022-05-06. (19/14820-6, 19/05616-6, 16/00006-7, 20/08637-1, 20/07860-9, 19/14819-8)

FIGUEIREDO, CAMILLE PINTO; PEREZ, MARIANA ORTEGA; SALES, LUCAS PEIXOTO; DOMICIANO, DIOGO SOUZA; SAMPAIO-BARROS, MARILIA M.; CAPARBO, VALERIA DE FALCO; RODRIGUES PEREIRA, ROSA MARIA. Lower hand grip in rheumatoid arthritis patients is associated with low finite element analysis using high resolution peripheral quantitative computed tomography scan of the 2nd metacarpophalangeal joint. INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES, v. N/A, p. 8-pg., 2022-06-29. (16/00006-7, 18/01315-9)

ESTEVES, GABRIEL P.; MAZZOLANI, BRUNA CARUSO; SMAIRA, FABIANA INFANTE; SANTO ANDRE, HELOISA C.; IRAHA, AMANDA YURI; ASTLEY, CAMILLA; MARQUES, ISABELA GOUVEIA; AMARANTE, MILLA CORDEIRO; REZENDE, NATHALIA SAFFIOTI; SIECZKOWSKA, SOFIA MENDES; et al. Food consumption based on processing level (according to Nova system) during the COVID-19 pandemic among adolescents with immunocompromised conditions: a case-control study. FRONTIERS IN NUTRITION, v. 10, p. 9-pg., 2023-05-16. (21/02742-0, 19/14820-6, 17/13552-2, 15/26937-4, 20/07860-9, 15/03756-4, 20/02741-1, 19/20814-9, 16/00006-7, 19/14819-8, 19/15231-4)

JALES NETO, LEVI H.; WICIK, ZOFIA; TORRES, GEORGEA H. F.; TAKAYAMA, LILIAM; CAPARBO, VALERIA F.; LOPES, NEUZA H. M.; PEREIRA, ALEXANDRE C.; PEREIRA, ROSA M. R.. Overexpression of SNTG2, TRAF3IP2, and ITGA6 transcripts is associated with osteoporotic vertebral fracture in elderly women from community. MOLECULAR GENETICS & GENOMIC MEDICINE, v. 8, n. 9, p. 12-pg., 2020-06-30. (16/00006-7)

FIGUEIREDO, CAMILLE P.; PEREZ, MARIANA O.; SALES, LUCAS PEIXOTO; SCHETT, GEORG; PEREIRA, ROSA M. R.. HR-pQCTin vivoimaging of periarticular bone changes in chronic inflammatory diseases: Data from acquisition to impact on treatment indications. MODERN RHEUMATOLOGY, v. 31, n. 2, p. 9-pg., 2020-08-28. (16/00006-7, 18/01315-9)

FIGUEIREDO, CAMILLE; PEREZ, MARIANA; DE MEDEIROS RIBEIRO, ANA CRISTINA; CAPARBO, VALERIA; PEREIRA, ROSA. Cortical Bone Erosion in the 2nd Metacarpal Bone Head: Association with Its Bone Mineral Density by HR-pQCT in Rheumatoid Arthritis Patients. ARTHRITIS & RHEUMATOLOGY, v. 71, p. 2-pg., 2019-10-01. (18/01315-9, 16/00006-7)