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Evaluation of bone parameters obtained by histomorphometry, HR-pQCT and trabecular bone score in patients with Rheumatoid Arthritis

Grant number: 18/05596-2
Support type:Scholarships in Brazil - Doctorate (Direct)
Effective date (Start): April 01, 2018
Effective date (End): March 31, 2022
Field of knowledge:Health Sciences - Medicine - Medical Clinics
Principal researcher:Rosa Maria Rodrigues Pereira
Grantee:Mariana Ortega Perez
Home Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Associated research grant:16/00006-7 - Evaluation of bone metabolism parameters by HR-pQCT and histomorphometry in rheumatoid arthritis and juvenile idiopathic arthritis patients: association with clinical and genetic variables, AP.TEM


Rheumatoid Arthritis (RA) is a chronic, autoimmune, inflammatory disease that affects women aged 40-50 years with chronic polyarthritis, often associated with deformity and disability. The primary RA lesion occurs in the articular synovium and the subchondral bone invasion represents the localized bone involvement. Patients with RA also have a generalized bone involvement, with alteration of bone microcachirecture, reduction of bone mass, bone fragility and greater risk of fractures. There are no studies in the literature evaluating local and generalized bone involvement in RA patients using bone histomorphometry, High-Resolution peripheral Quantitative Computed Tomography (HR-pQCT), and bone Trabecular Score (TBS) simultaneously. (AU)