Comparison of mechanisms of bone loss in patients undergoing Roux-en-Y gastric bypass or sleeve gastrectomy

• Grant number: 19/24782-4
• Support type: Scholarships in Brazil - Post-Doctorate
• Effective date (Start): September 01, 2020
• Effective date (End): August 31, 2022
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Principal Investigator: Rosa Maria Rodrigues Pereira
• Grantee: Igor Hisashi Murai
• Home Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Associated research grant: 16/00006-7 - Evaluation of bone metabolism parameters by HR-pQCT and histomorphometry in rheumatoid arthritis and juvenile idiopathic arthritis patients: association with clinical and genetic variables, AP.TEM

Abstract

The research project elaborated in this proposal follows the candidate's doctorate research line (FAPESP 15/02833-5 and 16/10993-5), which aimed to evaluate the effects of exercise training on bone metabolism in women with severe Obesity after bariatric surgery. Bariatric surgery is the treatment of choice for severe Obesity, as this is the only intervention capable of inducing a significant weight loss in this condition, resulting in an improvement and/or complete remission of the Obesity-related comorbidities. However, bariatric surgery-induced bone loss has been consistently reported in previous studies, which may increase the fracture risk. Despite a growing body of evidence showing bone loss after bariatric surgery in recent years, little is known about the mechanisms that cause this biological phenomenon in different surgical procedures. Therefore, this project aims to compare the mechanisms of bone loss in women undergoing the most common bariatric surgery procedures, which are the Roux-en-Y Gastric Bypass (RYGB) or Sleeve Gastrectomy (SG). In order to test our hypothesis, 30 women with severe Obesity, 15 of them eligible for RYGB and 15 for SG, will be submitted to bone metabolism assessments, including iliac crest bone biopsy in order to evaluate the cellular and molecular mechanisms of bone tissue deterioration; bone densitometry; high-resolution peripheral quantitative computed tomography; blood samples to evaluate bone turnover markers and; body composition, before and 12 months after surgery. A mixed model analysis for repeated measures will be performed to assess the effects of surgical procedures on bone parameters along the time, and Tukey post hoc will be employed for multiple comparisons. The significance level for testing null hypothesis will be 5%. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

MURAI, IGOR H.; FERNANDES, ALAN L.; SALES, LUCAS P.; PINTO, ANA J.; GOESSLER, KARLA F.; DURAN, CAMILA S. C.; SILVA, CARLA B. R.; FRANCO, ANDRE S.; MACEDO, MARINA B.; DALMOLIN, HENRIQUE H. H.; BAGGIO, JANAINA; BALBI, GUILHERME G. M.; REIS, BRUNA Z.; ANTONANGELO, LEILA; CAPARBO, VALERIA F.; GUALANO, BRUNO; PEREIRA, ROSA M. R. Effect of a Single High Dose of Vitamin D-3 on Hospital Length of Stay in Patients With Moderate to Severe COVID-19 A Randomized Clinical Trial. JAMA, v. 325, n. 11 FEB 2021. Web of Science Citations: 1.