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The roles of extracellular chaperones and miro-1 in protein aggregation related with Parkinson's Disease

Grant number: 18/09246-6
Support type:Scholarships abroad - Research
Effective date (Start): September 01, 2018
Effective date (End): February 28, 2019
Field of knowledge:Biological Sciences - Morphology
Principal Investigator:Merari de Fátima Ramires Ferrari
Grantee:Merari de Fátima Ramires Ferrari
Host: Mark Richard Wilson
Home Institution: Instituto de Biociências (IB). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Local de pesquisa : University of Wollongong (UOW), Australia  

Abstract

This scientific exchange will greatly improve understanding of processes related to protein aggregation that are associated with neurodegenerative disease. This collaboration will help for the first time initiate a detailed study on the role of extracellular chaperones in regulating the cell-cell propagation of protein aggregation "seeds" in an experimental model of Parkinson's Disease. The objective of the present study is to evaluate the effects of Miro-1 knockdown upon the expression of extracelular chaperones (clusterin, alpha 2 macroglobulin and haptoglobin) and aggregation of alpha-synuclein. We also intend to apply the knowledge achieved during PD model analysis to other models of protein aggregation (Alzheimer's disease, Amyotrophic Lateral Sclerosis) in a joint research project to be elaborated after this exchange.