THE ROLES OF EXTRACELLULAR CHAPERONES AND MIRO-1 IN PROTEIN AGGREGATION RELATED WITH PARKINSON'S DISEASE.

• Grant number: 18/09246-6
• Support Opportunities: Scholarships abroad - Research
• Start date until: September 01, 2018
• End date until: February 28, 2019
• Field of knowledge: Biological Sciences - Morphology - Cytology and Cell Biology
• Principal Investigator: Merari de Fátima Ramires Ferrari
• Grantee: Merari de Fátima Ramires Ferrari
• Host Investigator: Mark Richard Wilson
• Host Institution: Instituto de Biociências (IB). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Institution abroad: University of Wollongong (UOW), Australia

Abstract

This scientific exchange will greatly improve understanding of processes related to protein aggregation that are associated with neurodegenerative disease. This collaboration will help for the first time initiate a detailed study on the role of extracellular chaperones in regulating the cell-cell propagation of protein aggregation "seeds" in an experimental model of Parkinson's Disease. The objective of the present study is to evaluate the effects of Miro-1 knockdown upon the expression of extracelular chaperones (clusterin, alpha 2 macroglobulin and haptoglobin) and aggregation of alpha-synuclein. We also intend to apply the knowledge achieved during PD model analysis to other models of protein aggregation (Alzheimer's disease, Amyotrophic Lateral Sclerosis) in a joint research project to be elaborated after this exchange.