Immunohistochemical assessment and the mechanism of interference between kidneys during unilateral ischemia and reperfusion

• Grant number: 18/12134-5
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: October 01, 2018
• End date: September 30, 2019
• Field of knowledge: Health Sciences - Medicine - Surgery
• Principal Investigator: Nelson Wolosker
• Grantee: Carolina Rodrigues Dal Bo
• Host Institution: Instituto Israelita de Ensino e Pesquisa Albert Einstein (IIEPAE). Sociedade Beneficente Israelita Brasileira Albert Einstein (SBIBAE). São Paulo , SP, Brazil

Abstract

Experimental studies have demonstrated that unilateral renal ischemia can cause damage to the non-ischemic counter-lateral kidney through an inflammatory mechanism described as kidney-kidney crosstalk. The crosstalk phenomenon seems to be influenced by the clamping time and the type of clamping used: exclusive renal artery or renal artery and vein simultaneously. The purpose of this research is to perform an immunohistochemical study on renal biopsies of pigs in order to identify immune markers capable of confirming the mechanism of crosstalk between ischemic and non ischemic kidneys.