Spectral characteristics of local field potentials recorded in subthalamic nucleus in patients with Parkinson Disease

• Grant number: 18/14283-8
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: November 01, 2018
• End date: October 31, 2019
• Field of knowledge: Engineering - Biomedical Engineering
• Principal Investigator: André Kazuo Takahata
• Grantee: Bruno Leonardo Bianqueti
• Host Institution: Centro de Engenharia, Modelagem e Ciências Sociais Aplicadas (CECS). Universidade Federal do ABC (UFABC). Ministério da Educação (Brasil). Santo André , SP, Brazil

Abstract

Parkinson's disease (PD) is a disease of inexact origin that causes cell death in the substantia nigra, triggering motor symptoms such as rest tremor, bradykinesia, rigidity and changes in gait. The advancement of the disease tends to make the drug treatment inefficient, and neurosurgery for the implantation of deep brain stimulation electrodes is the main resource to soften the motor symptoms. The need for electrophysiological monitoring for the accurate implantation of the electrodes has opened up an important perspective for obtaining electrophysiological data for the study of PD, both by recording local field potentials (LFPs) as also by recording action potentials (spikes) in several structures of the basal ganglia, especially the subthalamic nucleus (STN). This scientific initiation project aims to create a database from records of LFPs collected during surgery to implant electrodes in the STN, as well as the better understanding of the components in frequency that make up the observed signal and its alterations through the induction of movement. The work defines a first step of a long-term collaboration between the group of Neurosurgery coordinated by Dr. Fábio Godinho with the signal processing group of UFABC coordinated by Prof. Diogo Soriano, which aim to correlate electrophysiological attributes obtained from deep brain recording with the different clinical symptoms or subtypes of PD

Scientific publications

(5)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

GODINHO, FABIO; FIM NETO, ARNALDO; BIANQUETI, BRUNO LEONARDO; DE LUCCAS, JULIA BALDI; VARJAO, EDUARDO; TERZIAN FILHO, PAULO ROBERTO; FIGUEIREDO, EBERVAL GADELHA; ALMEIDA, TIAGO PAGGI; YONEYAMA, TAKASHI; TAKAHATA, ANDRE KAZUO; et al. Spectral characteristics of subthalamic nucleus local field potentials in Parkinson's disease: Phenotype and movement matter. European Journal of Neuroscience, v. 53, n. 8, FEB 2021. (19/09512-0, 18/14285-0, 13/07559-3, 18/14283-8, 18/02251-4, 17/00319-8)

NETO, ARNALDO FIM; DE LUCCAS, JULIA BALDI; BIANQUETI, BRUNO LEONARDO; DA SILVA, LUIZ RICARDO; ALMEIDA, TIAGO PAGGI; TAKAHATA, ANDRE KAZUO; TEIXEIRA, MANOEL JACOBSEN; FIGUEIREDO, EBERVAL GADELHA; NASUTO, SLAWOMIR J.; GUIMARAES ROCHA, MARIA SHEILA; et al. Subthalamic low beta bursts differ in Parkinson's disease phenotypes. CLINICAL NEUROPHYSIOLOGY, v. 140, p. 14-pg., 2022-08-01. (18/14285-0, 19/09512-0, 13/07559-3, 17/00319-8, 18/14283-8, 18/02251-4)

FIM NETO, A.; DE LUCCAS, J. B.; BIANQUETI, B. L.; ROCHA, M. S.; NASUTO, S. J.; GODINHO, F.; SORIANO, D. C.; BASTOS-FILHO, TF; CALDEIRA, EMD; FRIZERA-NETO, A. Subthalamic Beta Burst Dynamics Differs for Parkinson's Disease Phenotypes. XXVII BRAZILIAN CONGRESS ON BIOMEDICAL ENGINEERING, CBEB 2020, v. N/A, p. 6-pg., 2022-01-01. (18/14285-0, 19/09512-0, 13/07559-3, 17/00319-8, 18/14283-8)

DE LUCCAS, J. B.; BIANQUETI, B. L.; FIM NETO, A.; ROCHA, M. S.; TAKAHATA, A. K.; SORIANO, D. C.; GODINHO, F.; BASTOS-FILHO, TF; CALDEIRA, EMD; FRIZERA-NETO, A. Subthalamic Field Potentials in Parkinson's Disease Encodes Motor Symptoms Severity and Asymmetry. XXVII BRAZILIAN CONGRESS ON BIOMEDICAL ENGINEERING, CBEB 2020, v. N/A, p. 7-pg., 2022-01-01. (18/14285-0, 19/09512-0, 13/07559-3, 17/00319-8, 18/14283-8)

FIM NETO, ARNALDO; DE LUCCAS, JULIA BALDI; BIANQUENTI, BRUNO LEONARDO; ALMEIDA, TIAGO PAGGI; ROCHA, MARIA SHEILA; YONEYAMA, TAKASHI; FRANCESCHI GODINHO, FABIO LUIZ; SORIANO, DIOGO COUTINHO; DIAZ, CAG; GONZALEZ, CC; et al. Estimation of Beta Burst Durations from Subthalamic Nucleus Local Field Potentials in Parkinson's Disease Through Hilbert and Continuous Wavelets Transforms. VIII LATIN AMERICAN CONFERENCE ON BIOMEDICAL ENGINEERING AND XLII NATIONAL CONFERENCE ON BIOMEDICAL ENGINEERING, v. 75, p. 6-pg., 2020-01-01. (18/14283-8, 18/14285-0, 13/07559-3, 17/00319-8)