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Analysis of oscillatory patterns of intrasurgical recordings in deep brain stimulation for Parkinson's Disease

Grant number: 11/21138-5
Support type:Scholarships in Brazil - Post-Doctorate
Effective date (Start): April 01, 2012
Effective date (End): March 31, 2014
Field of knowledge:Engineering - Biomedical Engineering
Principal Investigator:Koichi Sameshima
Grantee:Gerson Florence Carvalheira de Azevedo
Home Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil


The deep brain stimulation (DBS) has been investigated as a therapeutic method for patients with Parkinson's disease (PD) refractory to standard treatments. The reversible effects of DBS reduce the risk of undesirable permanent outcomes that may occur in ablative neurosurgical procedures. This method consists of stereotactic implantation of deep electrodes in specific targets. These electrodes are connected to an implantable neurostimulator. A main target of DBS is the subthalamic nucleus (STN). This target is located by stereotactic method in association with one or more imaging modalities. Due to the inaccuracies of imaging method in determining precisely the coordinates of these areas, the neurophysiological mapping is necessary, which is performed through the micro and/or macro-stimulation and intra-operative recordings using micro-electrodes. These recordings allow for the identification of abnormal oscillatory patterns in the STN. Analyses of these patterns may help to identify the best location for DBS implantation. Within this context, in order to understand the dynamics of STN's oscillatory patterns and thereby contribute to the identification of the optimal site for the DBS implantation, this project aims at analyzing the oscillatory patterns of intra-surgical records from patients with PD, investigating their influence on the effectiveness of the DBS therapy. This study will evaluate electrophysiological recordings from 30 patients. These records will be studied based on mathematical methods of signal processing and analysis.

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
FLORENCE, GERSON; SAMESHIMA, KOICHI; FONOFF, ERICH T.; HAMANI, CLEMENT. Deep Brain Stimulation: More Complex than the Inhibition of Cells and Excitation of Fibers. NEUROSCIENTIST, v. 22, n. 4, p. 332-345, AUG 2016. Web of Science Citations: 24.
FLORENCE, G.; KURTHS, J.; MACHADO, B. S.; FONOFF, E. T.; CERDEIRA, H. A.; TEIXEIRA, M. J.; SAMESHIMA, K. Neuronal excitability level transition induced by electrical stimulation. European Physical Journal-Special Topics, v. 223, n. 13, p. 2913-2922, DEC 2014. Web of Science Citations: 1.
RODRIGUES, A. C.; MACHADO, B. S.; FLORENCE, G.; HAMAD, A. P.; SAKAMOTO, A. C.; FUJITA, A.; BACCALA, L. A.; AMARO, JR., E.; SAMESHIMA, K. Brain network dynamics characterization in epileptic seizures. European Physical Journal-Special Topics, v. 223, n. 13, p. 2933-2941, DEC 2014. Web of Science Citations: 8.

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