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Micelle-to-vesicle transition technique applied to investigate the effect of the insecticide acephate on lipid bilayers

Grant number: 18/23123-4
Support type:Scholarships abroad - Research Internship - Master's degree
Effective date (Start): March 01, 2019
Effective date (End): August 31, 2019
Field of knowledge:Physical Sciences and Mathematics - Physics - Condensed Matter Physics
Principal researcher:Carlos José Leopoldo Constantino
Grantee:Luis Fernando Do Carmo Morato
Supervisor abroad: Livia Giotta
Home Institution: Faculdade de Ciências e Tecnologia (FCT). Universidade Estadual Paulista (UNESP). Campus de Presidente Prudente. Presidente Prudente , SP, Brazil
Research place: Università del Salento, Italy  
Associated to the scholarship:18/01984-8 - Effects of acephate insecticide in simple models of lipid membrane based on Langmuir films and GUVs: molecular level interactions and morphological effects, BP.MS


Mimetic systems of cellular membrane are widely used as alternative technique to study interactions that are difficult to be carried out in vivo and in vitro studies. This project has as main objective the study of interactions between acephate - an insecticide which has toxic potentials - and lipid vesicles (bilayers) formed by micelle-to-vesicle transition (MVT), a simple and convenient technique. The vesicles will be composed by five different lipids, which are DPPC (a zwitterionic phospholipid) and four other ones that share chemical groups in their heads, but have the same alkyl chain: DODAB, DHP, DPTAP and DPPA. These lipid supramolecular structures will be assembled in presence and absence of the pesticide, and characterized by UV-visible/NIR (ultraviolet-visible/near infrared) spectroscopy, Attenuated Total Reflectance Fourier Transform Infrared (ATR-FTIR) spectroscopy, and DLS (Dynamic Light Scattering). (AU)

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