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Study of proteases and their substrates from Atta Sexdens using degradomics approaches

Grant number: 18/21746-4
Support type:Scholarships abroad - Research Internship - Post-doctor
Effective date (Start): January 21, 2019
Effective date (End): September 30, 2019
Field of knowledge:Physical Sciences and Mathematics - Chemistry - Organic Chemistry
Principal Investigator:João Batista Fernandes
Grantee:Hugo César Ramos de Jesus
Supervisor abroad: Christopher Overall
Home Institution: Centro de Ciências Exatas e de Tecnologia (CCET). Universidade Federal de São Carlos (UFSCAR). São Carlos , SP, Brazil
Local de pesquisa : University of British Columbia (UBC), Canada  
Associated to the scholarship:17/15455-4 - Contribution to integrated studies for leaf-cutting ants control: search for new insecticides and fungicides - nanoencapsulation, BP.PD


Proteases are responsible for regulate a wide range of essential cellular processes in all living organisms. They are a major group of hydrolytic enzymes in insects and are vital for proper cellular functioning in several physiological events such as reproduction, development, digestion, proenzyme activation, immune response amongst others. Accordingly, these enzymes are particularly promising targets for developing strategies for the control of agricultural pests. Through the use of approaches from the relatively new field of degradomics, it is possible to uncover the biological roles and molecular features of proteases in culture or in vivo. Thus, we will use degradomics approaches to identify proteases and their substrates in Atta sexdens. This will allow our understanding of physiological roles of these enzymes and thereby point to effective and sustainable A. sexdens control strategies. In addition, we will develop a hybrid method based on the cross-linking technique and degradomics approaches for identification and mapping of the molecular interactions between proteases and other proteins.