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Multiresponsive triblock copolymers based on poly(oligo(ethylene glycol) methyl ether methacrylate) and poly(4-vinylpyridine): synthesis and solution properties

Grant number: 17/24938-9
Support Opportunities:Scholarships in Brazil - Doctorate
Effective date (Start): January 01, 2019
Effective date (End): November 30, 2021
Field of knowledge:Physical Sciences and Mathematics - Chemistry - Physical-Chemistry
Principal Investigator:Maria Isabel Felisberti
Grantee:Daniela de Morais Zanata
Host Institution: Instituto de Química (IQ). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
Associated research grant:15/25406-5 - Organizing matter: colloids formed by association of surfactants, polymers and nanoparticles, AP.TEM


Block copolymers have attracted the interest of many research groups, especially due to self-assembly capability. Self-assembly can result in different morphologies and, consequently, systems with different properties. The combination of responsive polymers blocks results in copolymers, which properties, for example, in solution and self-assembly behavior are affected by environment conditions as temperature, pH, and others. Therefore, responsive block copolymers had been widely applied in biomedical area, particularly in drug delivery systems. In this context, this project aims the study of triblock copolymers based on poly(oligo(ethylene glycol) methyl ether methacrylate) (POEGMA), a thermoresponsive polymer and poly(4-vinylpyridine) (P4VP), a pH-responsive polymer, as multiresponsive material. The response of these copolymers to variations in the environment in which they are present, in principle, can be modulated by composition and architecture. Reversible additionfragmentation chain-transfer polymerization technique (RAFT), which allows the achievement of copolymers with controlled composition and architecture, will be used to the copolymers POEGMA-b-P4VP-b-POEGMA and P4VP-b-POEGMA-b-P4VP synthesis. The self-assembly behavior of these triblock copolymers in solution will be studied in relation to changes at temperature, at pH, by solvent and concentration. The sol-gel behavior of these triblock copolymers will be also evaluated, aiming the achievement of a free-standing gel from this copolymers, altering only physical-chemical parameters and without the addition of crosslinking agent. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
POLO FONSECA, LUCAS; ZANATA, DANIELA DE MORAIS; GAUCHE, CONY; FELISBERTI, MARIA ISABEL. A one-pot, solvent-free, and controlled synthetic route for thermoresponsive hyperbranched polyurethanes. Polymer Chemistry, v. 11, n. 39, p. 6295-6307, . (17/24938-9, 17/03202-4, 15/25406-5)
ZANATA, DANIELA DE MORAIS; FELISBERTI, MARIA ISABEL. Thermo- and pH-responsive POEGMA-b-PDMAEMA-b-POEGMA triblock copolymers. EUROPEAN POLYMER JOURNAL, v. 167, p. 13-pg., . (17/24938-9, 15/25406-5)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
ZANATA, Daniela de Morais. Temperature and pH-responsive triblock copolymers: synthesis and solution properties. 2021. Doctoral Thesis - Universidade Estadual de Campinas (UNICAMP). Instituto de Química Campinas, SP.

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