Gene interference on the dorsol motor of vagus neurons and its influence on the autonomic dysfunctions of spontaneously hypertensive rats

• Grant number: 18/19907-0
• Support Opportunities: Scholarships in Brazil - Doctorate (Direct)
• Start date: January 01, 2019
• End date: April 30, 2023
• Field of knowledge: Biological Sciences - Physiology - Physiology of Organs and Systems
• Principal Investigator: Vagner Roberto Antunes
• Grantee: Karoline Martins dos Santos
• Host Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Associated scholarship(s): 21/10017-4 - Properties of liver-related PVN-DMV neurons and their role in facilitating the effects of central insulin, BE.EP.DD

Abstract

I present in this document a proposal of scientific project with the objective of changing scholarship of masters level for a direct doctorate, before my approval on course transference (master to doctorate) happened during the qualification exam. The first objectives proposed on masters project have been achieved until the date, and with the approval to changing of level, we are proposing to expand the project to the doctorate level with experimental approach and methodologies more innovative to answer some questions that appeared during the project's development. Our proposal is to extend the studies on the evaluation of electrophysiological properties of dorsal motor of the vagus neurons that have projections exclusively to the hepatic region on spontaneously hypertensive rats, and its normotensive controls, against pharmacogenetic (DREADD) and non-pharmacological (physical exercise) therapies, detailed all over the document. Furthermore, it is important to highlight that the results obtained so far were presented at the last annual meeting of Federation of Societies of Experimental Biology (FesBE) and my project received the first place in Álvaro Osório de Almeida Award granted by the Brazilian Society of Physiology (SBFis) to young scientists with outstanding and excellence works. Therefore, we hope to count with the appreciation in the judgment of this proposal to change the scholarship level. (AU)

Scientific publications

(The scientific publications listed on this page originate from the Web of Science or SciELO databases. Their authors have cited FAPESP grant or fellowship project numbers awarded to Principal Investigators or Fellowship Recipients, whether or not they are among the authors. This information is collected automatically and retrieved directly from those bibliometric databases.)

SA, RENATO W. MARTINS; THEPARAMBIL, SHEFEEQ M.; DOS SANTOS, KAROLINE MARTINS; CHRISTIE, ISABEL N.; MARINA, NEPHTALI; CARDOSO, BARBARA V.; HOSFORD, PATRICK S.; ANTUNES, VAGNER R.. Salt-loading promotes extracellular ATP release mediated by glial cells in the hypothalamic paraventricular nucleus of rats. Molecular and Cellular Neuroscience, v. 124, p. 9-pg., 2023-01-18. (19/19894-8, 16/21991-3, 16/03359-8, 18/19907-0)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

SANTOS, Karoline Martins dos. Neuroanatomical and functional study on the axis of the Paraventricular Nucleus of Hypothalamus Dorsal Motor of the Vagus Nucleus and liver involved in the control of glycemia resulting from the action of insulin in the central nervous system. 2023. Doctoral Thesis - Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB/SDI) São Paulo.