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Effect of curcumin-based dietary supplementation on bone resorption of Wistar rats with apical periodontitis

Grant number: 18/18661-7
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): January 01, 2019
Effective date (End): December 31, 2020
Field of knowledge:Health Sciences - Dentistry - Endodontics
Principal researcher:Luciano Tavares Angelo Cintra
Grantee:Mariana Pagliusi Justo
Home Institution: Faculdade de Odontologia (FOA). Universidade Estadual Paulista (UNESP). Campus de Araçatuba. Araçatuba , SP, Brazil

Abstract

Previous studies from our research group (FAPESP Process 2012/02083-8; 2012/02565-2, 2013/26390-0, 2014/10324-0, 2015/03054-0, 2016/08005-0) demonstrated in an animal model that endodontic infection exerts effects on systemic health as well as certain systemic changes can modulate the development of endodontic infection. Thus, we believe it is important to study therapies that modulate the process of bone resorption resulting from endodontic infection, in order to minimize its systemic effects. The aim of this study will be to verify if the effect of curcumin-based dietary supplementation on the bone resorption in rats with apical periodontitis. 40 rats will be used divided into 4 groups of 10 animals each: C - control rats; C + CUR - rats supplemented with curcumin; PA - rats with apical periodontitis; PA + CUR - rats with apical periodontitis and supplemented with curcumin. The curcumin will be determined by gavage for 15 days before the induction of root canal infection and 30 days after induction, total of 45 days of supplementation. The apical periodontitis will be induced by pulp exposure of the first and second upper molars and lower right side of each animal. After 30 days, the jaws will be collected and processed for histological and histometric analysis of the periapical region. The results of the different analyzes will be analyzed by specific statistical tests for each case (p<0.05).

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