Environmental Nanoscience - Understanding the impacts of nanomaterial eco-corona formation on toxicity and working towards a Brazil-EU nanosafety research e-infrastructure

• Grant number: 18/25140-3
• Support Opportunities: Scholarships abroad - Research
• Start date: June 01, 2019
• End date: May 31, 2020
• Field of knowledge: Physical Sciences and Mathematics - Chemistry
• Principal Investigator: Diego Stéfani Teodoro Martinez
• Grantee: Diego Stéfani Teodoro Martinez
• Host Investigator: Iseult Lynch
• Host Institution: Centro Nacional de Pesquisa em Energia e Materiais (CNPEM). Ministério da Ciência, Tecnologia e Inovação (Brasil). Campinas , SP, Brazil
• Institution abroad: University of Birmingham, England
• Associated research grant: 14/50906-9 - INCT 2014: in Functional Complex Materials, AP.TEM

Abstract

Understanding the interactions of nanomaterials with environmental and biological systems is essential for the safe innovation and responsible development of nanotechnology. In this direction, nano(eco)toxicity assessment, nanoinformatics and the regulation of nanomaterials are priority areas in the Brazil-EU Science & Technology cooperation roadmap (2018-2020). The aims of this visiting research project at the University of Birmingham (UoB) are: (1) to study the interaction of nanomaterials with natural organic matter isolated from Brazilian tropical soils and soil-biochar systems by performing analytical excellence characterization; (2) to evaluate the impacts of nanomaterial eco-corona formation on toxicity of nanomaterials in the Daphnia magna model, focusing on co-exposure protocols with other pollutants and metabolomics; and (3) to collaborate with the NanoCommons H2020 platform for developing a Brazil-EU nanosafety research e-infrastructure to support in silico toxicity assessment and nanoinformatics. Eco-coronas, Brazilian tropical soils, and sugarcane bagasse biochar are therefore key strategic and innovative systems in this scientific cooperation. Additionally, a nanomaterial library developed by UoB Environmental Nanoscience group will be utilized during this research cooperation for establishment of systematic nanomaterial structure-activity (effect) correlations. Finally, the execution of this project will contribute to the advancement of fundamental issues in environmental health and nanosafety research, promoting international cooperation towards open transnational access of harmonized nano-protocols, experimental data and safety-by-design approaches.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

MARTINEZ, DIEGO STEFANI T.; ELLIS, LAURA-JAYNE A.; DA SILVA, GABRIELA H.; PETRY, ROMANA; MEDEIROS, ALINE M. Z.; DAVOUDI, HOSSEIN HAYAT; PAPADIAMANTIS, ANASTASIOS G.; FAZZIO, ADALBERTO; AFANTITIS, ANTREAS; MELAGRAKI, GEORGIA; et al. Daphnia magna and mixture toxicity with nanomaterials - Current status and perspectives in data-driven risk prediction. NANO TODAY, v. 43, p. 37-pg., 2022-02-18. (18/25140-3, 19/07058-0)

MARTINEZ, DIEGO STEFANI T.; DA SILVA, GABRIELA H.; DE MEDEIROS, ALINE MARIA Z.; KHAN, LATIF U.; PAPADIAMANTIS, ANASTASIOS G.; LYNCH, ISEULT. Effect of the Albumin Corona on the Toxicity of Combined Graphene Oxide and Cadmium to Daphnia magna and Integration of the Datasets into the NanoCommons Knowledge Base. NANOMATERIALS, v. 10, n. 10, OCT 2020. (19/07058-0, 18/25140-3)

REILLY, KATIE; ELLIS, LAURA-JAYNE A.; DAVOUDI, HOSSEIN HAYAT; SUPIAN, SUFFEIYA; MAIA, MARCELLA T. T.; SILVA, GABRIELA H. H.; GUO, ZHILING; MARTINEZ, DIEGO STEFANI T.; LYNCH, ISEULT. Daphnia as a model organism to probe biological responses to nanomaterials-from individual to population effects via adverse outcome pathways. FRONTIERS IN TOXICOLOGY, v. 5, p. 21-pg., 2023-04-14. (18/25140-3)