| Grant number: | 18/18297-3 |
| Support Opportunities: | Scholarships in Brazil - Scientific Initiation |
| Start date: | March 01, 2019 |
| End date: | December 09, 2020 |
| Field of knowledge: | Agronomical Sciences - Veterinary Medicine - Animal Reproduction |
| Principal Investigator: | Mayra Elena Ortiz D' Avila Assumpcao |
| Grantee: | Larissa Araújo Stábile |
| Host Institution: | Faculdade de Medicina Veterinária e Zootecnia (FMVZ). Universidade de São Paulo (USP). São Paulo , SP, Brazil |
Abstract In the last years scientists has carry out studies about the effects of age on women reproductive performance, however few studies analyze male reproductive efficiency and age. Increased paternal age has been associated with the development of several disorders, neurological and metabolic, such as schizophrenia, autism, bipolar disorders, cancers. Reproductive disorders such as decreased pregnancy rate, fetal deaths, testicular dysfunction and dysfunction hormonal use to be related. Studying reproductive aspects in humans prospectively presents some difficulties, such as ethical and monetary questions, statistically enough time and number of samples, and the difficulty in raise homogeneous groups. The use of the murine in prospective experiments allows us to study how age can influence reproductive capacity. In this way it is possible create homogeneous groups and simplified experimental design. The aim of this study is to use different ages of murine, 4 months and 1.5 years, for evaluate of fertilization rates, embryo development in vitro and implantation in females of reproductive age, serving as a model for the male fertility study. | |
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