Spectral Differences of Local Field Potentials Recorded in Bilateral Subthalamic Nuclei of Patients with Parkinson's Disease

• Grant number: 18/14285-0
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: April 01, 2019
• End date: December 31, 2019
• Field of knowledge: Engineering - Biomedical Engineering - Medical Engineering
• Principal Investigator: André Kazuo Takahata
• Grantee: Julia Baldi de Luccas
• Host Institution: Centro de Engenharia, Modelagem e Ciências Sociais Aplicadas (CECS). Universidade Federal do ABC (UFABC). Santo André , SP, Brazil
• Associated research grant: 13/07559-3 - BRAINN - The Brazilian Institute of Neuroscience and Neurotechnology, AP.CEPID

Abstract

Parkinson's disease (PD) is an inexact cause of illness that causes cell death in the substantia nigra triggering motor symptoms such as tremor of rest, bradykinesia, motor rigidity and changes in gait. The advancement of the disease tends to make the drug treatment inefficient, and neurosurgery for the implantation of deep brain stimulation electrodes is the main intervention to soften the motor symptoms. The need for electrophysiological monitoring for the accurate deposition of the electrodes has opened up an important perspective for obtaining electrophysiological data for the study of PD, both by recording local field potentials (LFPs) as also by recording action potentials (spikes) in several structures of the basal ganglia, especially the subthalamic nucleus (STN). This scientific initiation project aims to identify the spectral differences in the LFP records of the motor portion of the STN of both cerebral hemispheres of Parkinsonian patients during the surgery for bilateral implant of electrodes for deep brain electrical stimulation. The aim of this study is to possibile unveil the correlation of the symptomatic asymmetries of the patients with the electrophysiological records of the contralateral STNs and their respective coefficients in frequency in the alpha and beta rhythms. This set of analyzes stands out for allowing comparisons and statistical analyzes in the intra-subject scenario. As a long-term objective, the work may contribute to the establishment of biomarkers of PD with potential relation with possible subtypes of the disease

Scientific publications

(6)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

GODINHO, FABIO; FIM NETO, ARNALDO; BIANQUETI, BRUNO LEONARDO; DE LUCCAS, JULIA BALDI; VARJAO, EDUARDO; TERZIAN FILHO, PAULO ROBERTO; FIGUEIREDO, EBERVAL GADELHA; ALMEIDA, TIAGO PAGGI; YONEYAMA, TAKASHI; TAKAHATA, ANDRE KAZUO; et al. Spectral characteristics of subthalamic nucleus local field potentials in Parkinson's disease: Phenotype and movement matter. European Journal of Neuroscience, v. 53, n. 8, FEB 2021. (19/09512-0, 18/14285-0, 13/07559-3, 18/14283-8, 18/02251-4, 17/00319-8)

NETO, ARNALDO FIM; DE LUCCAS, JULIA BALDI; BIANQUETI, BRUNO LEONARDO; DA SILVA, LUIZ RICARDO; ALMEIDA, TIAGO PAGGI; TAKAHATA, ANDRE KAZUO; TEIXEIRA, MANOEL JACOBSEN; FIGUEIREDO, EBERVAL GADELHA; NASUTO, SLAWOMIR J.; GUIMARAES ROCHA, MARIA SHEILA; et al. Subthalamic low beta bursts differ in Parkinson's disease phenotypes. CLINICAL NEUROPHYSIOLOGY, v. 140, p. 14-pg., 2022-08-01. (18/14285-0, 19/09512-0, 13/07559-3, 17/00319-8, 18/14283-8, 18/02251-4)

NETO, ARNALDO FIM; GODINHO, FABIO; DA SILVA, LUIZ RICARDO TRAJANO; DE LUCCAS, JULIA BALDI; TAKAHATA, ANDRE KAZUO; FIGUEIREDO, EBERVAL GADELHA; CARLOTTI JUNIOR, CARLOS GILBERTO; ROCHA, MARIA SHEILA GUIMARAES; SORIANO, DIOGO COUTINHO. Alpha and high beta subthalamic intermittent activity correlates with freezing of gait severity in Parkinson's disease. CLINICAL NEUROPHYSIOLOGY, v. 171, p. 10-pg., 2025-01-29. (18/14285-0, 13/07559-3, 22/03243-0)

FIM NETO, A.; DE LUCCAS, J. B.; BIANQUETI, B. L.; ROCHA, M. S.; NASUTO, S. J.; GODINHO, F.; SORIANO, D. C.; BASTOS-FILHO, TF; CALDEIRA, EMD; FRIZERA-NETO, A. Subthalamic Beta Burst Dynamics Differs for Parkinson's Disease Phenotypes. XXVII BRAZILIAN CONGRESS ON BIOMEDICAL ENGINEERING, CBEB 2020, v. N/A, p. 6-pg., 2022-01-01. (18/14285-0, 19/09512-0, 13/07559-3, 17/00319-8, 18/14283-8)

DE LUCCAS, J. B.; BIANQUETI, B. L.; FIM NETO, A.; ROCHA, M. S.; TAKAHATA, A. K.; SORIANO, D. C.; GODINHO, F.; BASTOS-FILHO, TF; CALDEIRA, EMD; FRIZERA-NETO, A. Subthalamic Field Potentials in Parkinson's Disease Encodes Motor Symptoms Severity and Asymmetry. XXVII BRAZILIAN CONGRESS ON BIOMEDICAL ENGINEERING, CBEB 2020, v. N/A, p. 7-pg., 2022-01-01. (18/14285-0, 19/09512-0, 13/07559-3, 17/00319-8, 18/14283-8)

FIM NETO, ARNALDO; DE LUCCAS, JULIA BALDI; BIANQUENTI, BRUNO LEONARDO; ALMEIDA, TIAGO PAGGI; ROCHA, MARIA SHEILA; YONEYAMA, TAKASHI; FRANCESCHI GODINHO, FABIO LUIZ; SORIANO, DIOGO COUTINHO; DIAZ, CAG; GONZALEZ, CC; et al. Estimation of Beta Burst Durations from Subthalamic Nucleus Local Field Potentials in Parkinson's Disease Through Hilbert and Continuous Wavelets Transforms. VIII LATIN AMERICAN CONFERENCE ON BIOMEDICAL ENGINEERING AND XLII NATIONAL CONFERENCE ON BIOMEDICAL ENGINEERING, v. 75, p. 6-pg., 2020-01-01. (18/14283-8, 18/14285-0, 13/07559-3, 17/00319-8)