Use of bisphosphonates and pentoxifylline on induced periodondititis bone modulation: study in rats

• Grant number: 18/24717-5
• Support Opportunities: Scholarships in Brazil - Master
• Start date: May 01, 2019
• End date: April 30, 2021
• Field of knowledge: Health Sciences - Dentistry - Periodontology
• Principal Investigator: Rosemary Adriana Chierici Marcantonio
• Grantee: Isabella Fernanda dos Santos
• Host Institution: Faculdade de Odontologia (FOAr). Universidade Estadual Paulista (UNESP). Campus de Araraquara. Araraquara , SP, Brazil

Abstract

The aim of this study will be to evaluate the process of periodontal bone repair when using the medicines: bisphosphonate (1 mg/kg/day) and pentoxifylline (50 mg/kg/day) on the prevention and/or treatment of induced periodontal disease. This project will be separated in 2 studies: Study 1: to evaluate if the medicines bisphosphonate and pentoxifylline interfere on the progression of induced periodontal disease. Animals will me divided: Control Group - saline (C); Pentoxifylline Group (PTX) and Bisphosphonate Group (BIS). The animals will receive the medicines for 60 days; then periodontal disease will be induced by ligatures on the second molar. In the moment the medicines administration will be interrupted. After 15 days the animals will be euthanized. Study 2: to evaluate if the medicines bisphosphonate and pentoxifylline interfere on the treatment of induced periodontal disease. Animals will be divided: Control Group - saline (C); Pentoxifylline Group (PTX) and Bisphosphonate Group (BIS). By the time the ligatures will be made the animais will start receiving the medicines until the moment they will be euthanized. After 15 days the ligatures will be removed. At this moments half of the animals will receive scaling and root planning with hand instruments (Control - CR, Pentoxifylline Group- PTX-R, and Bisphosphonate Group - BIS-R) and the other half of each group will not receive any treatment (Control - CR, Pentoxifylline Group - PTX, and Bisphosphonate Group - BIS). After the periods 7, 15 and 30 days the animals will be euthanized. For both studies microtomographics, histologics/histometrics and marker for bone remodeling immunohistochemichal analysis will be done. (AU)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

SANTOS, Isabella Fernanda dos. Use of bisphosphonates and pentoxifylline on induced periodontitis bone modulation. Study in rats. 2021. Master's Dissertation - Universidade Estadual Paulista (Unesp). Faculdade de Odontologia. Araraquara Araraquara.