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Computational fluid dynamics (CFD) study of a multiphase microorganism propagation step of a high-density bioreactor STR growth

Grant number: 19/06377-5
Support type:Scholarships in Brazil - Master
Effective date (Start): May 01, 2019
Effective date (End): April 30, 2021
Field of knowledge:Engineering - Chemical Engineering
Principal Investigator:José Luís de Paiva
Grantee:André Martins Berger Peralta
Home Institution: Escola Politécnica (EP). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Associated research grant:17/50343-2 - Institutional development plan in the area of digital transformation: advanced manufacturing and smart and sustainable cities (PDIp), AP.PDIP

Abstract

A study of a computational model for the performance simulation of bioreactors - agitated and aerated tanks - for a high-density cell growth is proposed. This research project is related to the area of bio-physics-chemical modeling of IPT's Institutional development plan (PDIP) in the area of Digital Transformation: Advanced Manufacturing and Sustainable Smart Cities (Fapesp Process 17/50343-2). The validation of the model will be made through literature data and experimental results acquired from LBI's - Laboratório de Biotecnologia Industrial (Industrial biotechnology lab) - pilot plant inserted in IPT's Bionanomanufacture center. It is intended to implement a multiphase flow model applied to the stage of propagation of microorganisms in STR bioreactor to obtain high density culture. The models will be implemented via ANSYS-CFX code and should consider the mass and momentum balances of the liquid and gas phases and mass transfer models. Different operating conditions will be investigated: capacity of the bioreactor, type of agitator, speed of rotation and gas flow and impact on the performance of the reactor for the system being studied. This way, there is a reduction in the number of laboratory tests and consequently the resulting costs. The mastery of these tools will provide an analysis of the usual scale-up procedures for bioreactors and the establishment of new criteria and procedures for the design of industrial scale bioreactors. (AU)