Application of enantioselective polymer membranes containing type-Pirkle chiral selector as chiral stationary phases for liquid chromatography

• Grant number: 19/09037-0
• Support Opportunities: Scholarships abroad - Research Internship - Doctorate
• Start date: August 26, 2019
• End date: August 25, 2020
• Field of knowledge: Engineering - Materials and Metallurgical Engineering
• Principal Investigator: Caio Marcio Paranhos da Silva
• Grantee: Priscila Vedovello
• Supervisor: Maria Elizabeth Tiritan
• Host Institution: Centro de Ciências Exatas e de Tecnologia (CCET). Universidade Federal de São Carlos (UFSCAR). São Carlos , SP, Brazil
• Institution abroad: Universidade do Porto (UP), Portugal
• Associated to the scholarship: 17/18331-4 - Development of enantioselective polymeric membranes using "pirkle"-type particles for resolution of chiral compounds, BP.DR

Abstract

Many pharmaceutical compounds are commercially available as racemate. However, the therapeutic activity may be associated with only one of the enantiomers while its pair may be toxic or exhibit a different therapeutic activity. Therefore, the resolution of racemates during the synthesis of new drugs is of extreme importance to obtain these substances in their enantiomerically pure form. Alternatives for obtaining chiral compounds in the enantiomerically pure form include enantioselective synthesis and separation of the conventional post-synthesis racemate. However, these techniques present a high cost by restricting the enantiomeric purification of drugs used in the treatment of neglected diseases, which require low cost. Therefore, the use of membranes has become promising for enantiomeric separation, due to the low cost and energy consumption, continuous operability, variety of materials, among others. This project will study the chiral resolution capacity of polymers membranes containing mesoporous material (MCM-41) grafted with type-Pirkle chiral selectors based on silica extracted from rice husk biomass. The objective is to evaluate the polymeric membranes containing MCM-41-Pirkle as to their efficiency of chiral selection, comparing it with a chiral stationary phase (CSP) type-Pirkle. The content incorporated, the membrane preparation method and the polymer-mesoporous material compatibility will be taken into account.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

VEDOVELLO, PRISCILA; COSTA, JOSE ARNALDO SANTANA; FERNANDES, CARLA; TIRITAN, MARIA ELIZABETH; PARANHO, CAIO MARCIO. Evaluation of chiral separation by Pirkle-type chiral selector based mixed matrix membranes. Separation and Purification Technology, v. 289, p. 14-pg., 2022-05-15. (17/06775-5, 13/07296-2, 17/18331-4, 19/09037-0)