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Application of enantioselective polymer membranes containing type-Pirkle chiral selector as chiral stationary phases for liquid chromatography

Grant number: 19/09037-0
Support type:Scholarships abroad - Research Internship - Doctorate
Effective date (Start): August 26, 2019
Effective date (End): August 25, 2020
Field of knowledge:Engineering - Materials and Metallurgical Engineering
Principal researcher:Caio Marcio Paranhos da Silva
Grantee:Priscila Vedovello
Supervisor abroad: Maria Elizabeth Tiritan
Home Institution: Centro de Ciências Exatas e de Tecnologia (CCET). Universidade Federal de São Carlos (UFSCAR). São Carlos , SP, Brazil
Research place: Universidade do Porto (UP), Portugal  
Associated to the scholarship:17/18331-4 - Development of enantioselective polymeric membranes using "pirkle"-type particles for resolution of chiral compounds, BP.DR

Abstract

Many pharmaceutical compounds are commercially available as racemate. However, the therapeutic activity may be associated with only one of the enantiomers while its pair may be toxic or exhibit a different therapeutic activity. Therefore, the resolution of racemates during the synthesis of new drugs is of extreme importance to obtain these substances in their enantiomerically pure form. Alternatives for obtaining chiral compounds in the enantiomerically pure form include enantioselective synthesis and separation of the conventional post-synthesis racemate. However, these techniques present a high cost by restricting the enantiomeric purification of drugs used in the treatment of neglected diseases, which require low cost. Therefore, the use of membranes has become promising for enantiomeric separation, due to the low cost and energy consumption, continuous operability, variety of materials, among others. This project will study the chiral resolution capacity of polymers membranes containing mesoporous material (MCM-41) grafted with type-Pirkle chiral selectors based on silica extracted from rice husk biomass. The objective is to evaluate the polymeric membranes containing MCM-41-Pirkle as to their efficiency of chiral selection, comparing it with a chiral stationary phase (CSP) type-Pirkle. The content incorporated, the membrane preparation method and the polymer-mesoporous material compatibility will be taken into account.

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