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Development of new multimodal diagnostic agents doped with lanthanides ions

Grant number: 19/06761-0
Support type:Scholarships abroad - Research Internship - Master's degree
Effective date (Start): September 16, 2019
Effective date (End): March 01, 2020
Field of knowledge:Health Sciences - Medicine
Principal Investigator:Lucas Alonso Rocha
Grantee:Susane Bonamin Moscardini
Supervisor abroad: Marc Verelst
Home Institution: Pró-Reitoria Adjunta de Pesquisa e Pós-Graduação. Universidade de Franca (UNIFRAN). Franca , SP, Brazil
Local de pesquisa : Centre d'Elaboration des Matériaux et d'Etudes Structurales (CEMES), France  
Associated to the scholarship:18/02387-3 - Obtaining of diagnostic agents based on niobium materials containing lanthanide ions, BP.MS

Abstract

The development of new diagnostic imaging agents able to differentiate tissue, organs or pathologies types of similar contrasting properties more efficiently and presenting low toxicity good biocompatibility motivates new studies due to its huge importance in the medical field. Owing to its advantages, such as low cost, deep penetration depth, high resolution, as well as facile image processing, magnetic resonance imaging and X-ray computed tomography imaging play important roles in the diagnosis, prognosis, and treatment of various diseases, receiving significant attention in both research and practice. On another hand, near-infrared fluorescent probes offer advantages of, very high sensitivity, reasonably high photon penetration, low light scattering and minimal autofluorescence from living tissues. This project aims the synthesis and characterization of upconversion nanoparticles based on niobium oxide containing lanthanides ions (Ln3+, where Ln3+ = Gd3+ or Dy3+, Tm3+, Yb3+ and Nd3+) for the development of new multimodal materials with applications in the medical imaging field.