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Association between left atrium volume and score of calcium of coronary arteries in patients in peritoneal dialysis

Grant number: 19/05912-4
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Effective date (Start): June 01, 2019
Effective date (End): May 31, 2021
Field of knowledge:Health Sciences - Medicine - Medical Clinics
Principal Investigator:Silméia Garcia Zanati Bazan
Grantee:Eduarda Baccarin Ferrari
Host Institution: Faculdade de Medicina (FMB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil


Cardiovascular disease is the leading cause of death in peritoneal dialysis patients. Vascular calcification contributes to an increased risk of cardiovascular events. The evaluation of coronary calcification by the Coronary Calcium Score has been shown to predict the incidence of acute myocardial infarction and death from cardiovascular disease in these patients. Left atrial size has also been associated with infarction and cardiovascular events. This study aims to assess whether left atrial size could also be a risk-stratified for coronary artery disease in this population. Objective: To evaluate the association between left atrial volume and coronary artery calcium score. Methods: Cross-sectional, prospective, unicentric study. All patients with CKD who underwent peritoneal dialysis of the Dialysis Unit of the Hospital das Clínicas of the Faculdade de Medicina de Botucatu - UNESP for at least three months, aged between 18 and 75 years, will be included. (<7 days), autoimmune disease, malignant neoplasia, unstable heart disease (acute coronary syndrome, decompensated heart failure, unstable arrhythmias), severe left ventricular systolic dysfunction (EF <30 %), significant pericardial effusion, severe mitral or aortic valve disease, primary hyperparathyroidism, calcium supplementation or use of calcium-based phosphorus binders. Data collection will include a questionnaire for demographic and clinical data, bioimpedance, anthropometry, laboratory tests, coronary artery calcium score, echocardiogram, and carotid ultrasonography. The sample size was estimated in 47 patients. Statistical analysis: Data will be expressed as the mean ± standard deviation, with a significance level of p <0.05. Statistical comparisons of individual groups will be made on the basis of Student's t-test while correlations between groups will be assessed by the Pearson or Spearman coefficient. Expected results: As a result, we expect to find a positive association between left atrial volume and coronary artery calcium score in patients undergoing peritoneal dialysis.

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