Bioactive Peptaibols of the fungus Hypocrea SP., isolated from Antarctic

• Grant number: 19/09625-0
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: June 01, 2019
• End date: May 31, 2020
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Organic Chemistry
• Principal Investigator: Roberto Gomes de Souza Berlinck
• Grantee: Lucas Rodrigues da Silva
• Host Institution: Instituto de Química de São Carlos (IQSC). Universidade de São Paulo (USP). São Carlos , SP, Brazil

Abstract

The present project aims at the discovery of bioactive compounds produced by microorganisms isolated from the Antarctic. In cold environments, there are extremophilic beings that have specific metabolisms due to stress situations. Few studies have investigated the composition and functionality of the microbiota of cold ecosystems. Finding bioactive substances produced by marine-derived fungal isolated from cold environments constitutes a strategy for the discovery of bioactive compounds potentially useful for the treatment of human diseases, such as Chagas disease, leishmaniasis, infections and certain types of cancer. The extracts of fungal isolated from the Antarctic continent presented biological activities. These extracts will undergo HPLC-UV-MS and UPLC-QTOF analyses and be subjected to bioguided isolation.