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Bioactive Peptaibols of the fungus Hypocrea SP., isolated from Antarctic

Grant number: 19/09625-0
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): June 01, 2019
Effective date (End): May 31, 2020
Field of knowledge:Physical Sciences and Mathematics - Chemistry - Organic Chemistry
Principal Investigator:Roberto Gomes de Souza Berlinck
Grantee:Lucas Rodrigues da Silva
Home Institution: Instituto de Química de São Carlos (IQSC). Universidade de São Paulo (USP). São Carlos , SP, Brazil

Abstract

The present project aims at the discovery of bioactive compounds produced by microorganisms isolated from the Antarctic. In cold environments, there are extremophilic beings that have specific metabolisms due to stress situations. Few studies have investigated the composition and functionality of the microbiota of cold ecosystems. Finding bioactive substances produced by marine-derived fungal isolated from cold environments constitutes a strategy for the discovery of bioactive compounds potentially useful for the treatment of human diseases, such as Chagas disease, leishmaniasis, infections and certain types of cancer. The extracts of fungal isolated from the Antarctic continent presented biological activities. These extracts will undergo HPLC-UV-MS and UPLC-QTOF analyses and be subjected to bioguided isolation.