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Studies of mechanisms of activation and action of MMP2 and ADAM17: identification of regulatory proteins, oxidant production pathways, epigenetics and proteolytic targets

Grant number: 19/10072-5
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): September 01, 2019
Effective date (End): August 31, 2020
Field of knowledge:Biological Sciences - Biochemistry - Enzymology
Principal Investigator:Raquel Fernanda Gerlach
Grantee:Renan Leonardi de Oliveira Rigotti
Home Institution: Faculdade de Odontologia de Ribeirão Preto (FORP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
Associated research grant:14/23888-0 - Studies on the activation mechanisms of MMP-2 and ADAM17: identification of regulatory proteins, oxidant production pathways, epigenetics and proteolytic targets, AP.TEM

Abstract

This project aims at learning how to produce and how to purify recombinant proteins, an important part of the work of Subprojects 3 and 4 of the Tematic Project. The student will carry out the kinetic analyses of each batch of recombinant protein.