Study of the influence of obesity and microbiota on acute kidney injury in the ischemia and reperfusion model

• Grant number: 18/23183-7
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: September 01, 2019
• End date: March 31, 2023
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Principal Investigator: Lucia da Conceição Andrade
• Grantee: Heloísa de Oliveira Jacobina
• Host Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

The current epidemic of obesity, given the sedentary lifestyle and the intense caloric diet, has triggered consequences to human health as the increase of the incidence of cardiovascular and metabolic diseases, as well as greater chances of the occurrence of acute episodes, for example, Acute Kidney Injury (AKI), which can lead to chronic conditions, for example, chronic kidney disease. Also, it is worth mentioning that the incidence of AKI has been increasing in recent years, given the increase in cardiac and hepatic dysfunctions, which are related to changes in hemodynamics and can cause prerenal AKI, exposure to toxins and ischemia, related to the occurrence of intrinsic renal AKI, and bilateral obstruction of the ureters, linked to post renal AKI. This abrupt increase in the occurrence of AKI is linked to a considerable increase in mortality and hospitalizations, as observed in the Hospital das Clínicas of the Faculty of Medicine of the University of São Paulo, which is the largest center for the care of AKI patients in Latin America. In view of the great discoveries regarding the microbiota and the functional and metabolic organization of the organism and the innumerable impacts to human health, for both obesity and AKI, this study proposes to analyze the possible interferences that the microbiota could have in the development of AKI in different biotypes (lean and obese).