Correlation of immunological factors with molecular and imaging findings: new therapeutic perspectives in glioblastoma

• Grant number: 19/14684-5
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: September 01, 2019
• End date: October 31, 2020
• Field of knowledge: Health Sciences - Medicine - Pathological Anatomy and Clinical Pathology
• Principal Investigator: Iuri Santana Neville Ribeiro
• Grantee: Vitor Jodar Cavalheiro
• Host Institution: Instituto do Câncer do Estado de São Paulo Octavio Frias de Oliveira (ICESP). Coordenadoria de Serviços de Saúde (CSS). Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil

Abstract

Glioblastoma (GBM) is the most common type of adults brain tumor. Treatment consists of continuous radiotherapy and chemotherapy, with a median survival of 15 to 20 months. Whereas unfavorable prognosis and the limited therapeutic options, the development of new therapies becomes necessary. The inflammatory modulation has a central function in the evolution of GBM, and cytokines may play a relevant role in diagnosis, prognosis and treatment. High levels of TNF-±, IL-1, IL-6, IL-8 and IFN³ are found in the tumor tissue of GBM patients. In addition, TGF-², IL-4, IL-10 and IL-13 may also affect the evolution of GBM. This project will evaluate the correlation between pro- and anti-inflammatory cytokines in tumor tissue and serum. In addition to neuroimaging aspects (volumetry, infiltrate area, necrosis, edema and MVB), and biomolecular aspects (HDI-1 maturation, 1p19q co-deletion, MGMT hypermethylation status) in patients with GBM who did not undergo treatments. A better understanding of this correlation between the inflammatory response and the tumor environment is essential for the development of a more effective target therapy for GBM patients