Study of encapsulation of bioactive glasses as graft for bone reconstruction

• Grant number: 19/15960-6
• Support Opportunities: Scholarships abroad - Research
• Start date: January 01, 2020
• End date: December 31, 2020
• Field of knowledge: Engineering - Materials and Metallurgical Engineering - Nonmetallic Materials
• Principal Investigator: Ivone Regina de Oliveira
• Grantee: Ivone Regina de Oliveira
• Host Investigator: João Paulo Ribeiro Miranda Borges
• Host Institution: Instituto de Pesquisa e Desenvolvimento (IP&D). Universidade do Vale do Paraíba (UNIVAP). São José dos Campos , SP, Brazil
• Institution abroad: Universidade Nova de Lisboa, Portugal

Abstract

Failures and defects in bone tissues culminate in cases of pseudoarthrosis or osteomyelitis whose treatment occurs by means of a surgical act aimed at the mechanical removal of the affected tissues, followed by the application of bone grafts. Although bioactive glasses have become very promising materials for this application, they do not have uniform particles in shape and size. Ideal systems for grafts should consist of microspheres with space for effective and functional bone regeneration as they allow internal bone growth and vascularization, together with properties suitable for bone regeneration such as bioactivity and the ability to release biologically active substances in a controlled manner after implantation. In this context, this work aims to conduct a systemic study on the development of bioactive glass microspheres as grafts for bone regeneration. Its development will include the synthesis and characterization of bioactive glass particles in the presence or absence of strontium by the sol-gel process; the production and characterization of bioactive microspheres by means of different encapsulation methods with biodegradable polymers and, finally, the evaluation of the performance of these composites in the regeneration of the bone tissue by in vitro and in vivo assays. Thus, the relevance and impact of the project for the technological development or innovation consists in the obtaining of bioactive microspheres which can release Sr ions that will stimulate the regeneration of the injured tissue accentuating the proliferation and differentiation of adhered cells on its surface. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

DE OLIVEIRA, IVONE REGINA; GONCALVES, ISABELA DOS SANTOS; DOS SANTOS, KENNEDY WALLACE; LANCA, MARIA CARMO; VIEIRA, TANIA; SILVA, JORGE CARVALHO; CENGIZ, IBRAHIM FATIH; REIS, RUI LUIS; OLIVEIRA, JOAQUIM MIGUEL; BORGES, JOAO PAULO MIRANDA RIBEIRO. Biocomposite Macrospheres Based on Strontium-Bioactive Glass for Application as Bone Fillers. ACS MATERIALS AU, v. N/A, p. 13-pg., 2023-08-01. (19/15960-6)

A.M. BARBOSA; K.W. DOS SANTOS; I. S. GONÇALVES; P.M.S.C.M. LEITE; A.S. MARTORANO; G. GRISOTE; L.M.S. CASTRO-RAUCCI; P.T. DE OLIVEIRA; L. RANIERO; I.R. OLIVEIRA. Calcium Aluminate Cement Blends Containing Bioactive Glass and Strontium for Biomaterial Applications. MATERIALS RESEARCH-IBERO-AMERICAN JOURNAL OF MATERIALS, v. 24, n. 6, 2021-10-01. (19/15960-6)

OLIVEIRA, I. R.; BARBOSA, A. M.; SANTOS, K. W.; LANCA, M. C.; LIMA, M. M. R. A.; VIEIRA, T.; SILVA, J. C.; BORGES, J. P.. Properties of strontium-containing BG 58S produced by alkali-mediated sol-gel process. CERAMICS INTERNATIONAL, v. 48, n. 8, p. 10-pg., 2022-03-16. (19/15960-6)