Drug bioavailability can be increased by numerous factors, among them the increase of its surface area. This parameter influences drug solubility in the matrices, allowing it to be more easily absorbed by the tissues. In this context, previous work was done with the aim of promoting the micronization of the anticancer drug imiquimod. After micronization of the drug, it is necessary to evaluate if, in fact, there was an increase in its bioavailability. Thus, this proposal aims to compare the drug penetration into the skin and buccal mucosa before and after the micronization process. For this, tests will be done ex vivo and the results will be used to characterize the way in which the drug penetrates on the studied tissues. Aqueous suspensions, hydrogels and films will be evaluated as drug delivery vehicles.
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