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Preventive effects of canabidiol in an animal model of schizophrenia in females: pre-natal immune activation by the administration of polyminosinic-polycitidylic acid

Grant number: 19/13054-8
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): November 01, 2019
Status:Discontinued
Field of knowledge:Biological Sciences - Pharmacology - Neuropsychopharmacology
Principal Investigator:Vanessa Costhek Abílio
Grantee:Gabriela Doná Rodrigues
Home Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil

Abstract

Schizophrenia is a highly debilitating neuropsychiatric disorder. Current treatments are not effective to all the symptoms, are associated with sever side-effects and do not benefit all the patients. Therefore, the search for preventive strategies is crucial. Recently, we have verified that cannabidiol prevents the development of schizophrenia-like behavioral alterations in the poly I:C schizophrenia model evaluate in male mice. Nevertheless, male and female subjects present differences in the course of schizophrenia as well as in the development of behavioral alterations in animal models of the disease. The aims of the present study are: 1) to extend the behavioral characterization of the poly I:C model in female mice; 2) to verify a possible preventive effect of CBD on the behavioral alterations in these female mice (as previously seen by us in males).